Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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SMD-3040
Item number: TGM-T79820-50mg
Description: SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), comprising an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the SMARCA4 protein and has demonstrated robust tumor growth inhibition in xenograft models...
| MW: | 943.21 D |
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DGKalpha-IN-2
Item number: TGM-T79821-50mg
Description: DGKalpha-IN-2 (example 48), a potent DGKalpha inhibitor with an IC50 of 0.9 nM, significantly enhances the anti-tumor efficacy of anti-PD-1 therapy by amplifying T cell proliferation and function, making it a valuable agent for cancer and immunological research. Target: Others
| CAS | 2648556-92-5 |
| MW: | 461.43 D |
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DGKalpha-IN-3
Item number: TGM-T79822-50mg
Description: DGKalpha-IN-3 (example 25), with an IC50 of 283 nM, is a selective DGKalpha inhibitor that enhances anti-PD-1's anti-tumor activity by promoting T cell proliferation and function, highlighting its potential for cancer and immunology research applications. Target: Others
| CAS | 2648418-86-2 |
| MW: | 500.51 D |
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DGKalpha-IN-4
Item number: TGM-T79823-50mg
Description: DGKalpha-IN-4 (example 432) is an inhibitor of DGKalpha with an IC50 value of 0.1 nM. This compound notably potentiates the anti-tumor efficacy of anti-PD-1 therapy by augmenting T cell proliferation and function and shows promise for research in cancer and immunology. Target: Others
| CAS | 2648723-43-5 |
| MW: | 523.58 D |
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DGKalpha-IN-4
Item number: TGM-T79824-50mg
Description: DGKalpha&zeta-IN-1 (Compound II) is a DGK inhibitor that enhances T-cell function and synergistically interacts with PD-1, providing therapeutic advantages in immune and tumor contexts [1]. Target: Others
| CAS | 2830643-06-4 |
| MW: | 542.61 D |
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DGKzeta-IN-4
Item number: TGM-T79825-50mg
Description: DGKzeta-IN-4, a DGK-zeta inhibitor, is utilized as an active ingredient in pharmaceutical formulations to treat cancers associated with immune cell activation or those resistant to anti-PD-1/anti-PD-L1 antibody treatments [1]. Target: Others
| CAS | 2778366-77-9 |
| MW: | 531.91 D |
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DGKalpha-IN-6
Item number: TGM-T79826-50mg
Description: DGKalpha-IN-6, a diacylglycerol kinase alpha (DGKalpha) inhibitor characterized by an inhibitory concentration (IC50) of 1.377 nM,holds promise for use in cancer research. Target: Others
| CAS | 2886734-91-2 |
| MW: | 462.47 D |
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DGKalpha-IN-7
Item number: TGM-T79827-50mg
Description: DGKalpha-IN-7 is a potent DGKalpha inhibitor with an IC50 value of 6.225 nM and potential applications in cancer research. Target: Others
| CAS | 2886092-50-6 |
| MW: | 472.41 D |
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DGKalpha-IN-8
Item number: TGM-T79828-50mg
Description: DGKalpha-IN-8 (Example 51), a potent diacylglycerol kinase alpha (DGKalpha) inhibitor, exhibits an IC50 of 22.491 nM and an EC50 of 0.256 nM. It is applicable in cancer research, particularly for solid tumors, and in studies of viral infections such as HIV and hepatitis B virus [1]. Target: Others
| CAS | 2886717-70-8 |
| MW: | 473.88 D |
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ASN90
Item number: TGM-T79829-50mg
Description: ASN90 is a specific, orally active inhibitor of the O-GlcNAcase (OGA) enzyme, demonstrating an IC50 of 10.2 nM. It is utilized in the research of neurodegenerative disorders including tauopathies and alpha-synucleinopathies [1]. Target: Others
| CAS | 1884154-02-2 |
| MW: | 375.45 D |
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PROTAC MLKL Degrader-1
Item number: TGM-T79831-50mg
Description: PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, with a degradation maximum (D max) exceeding 90%. The compound incorporates modified cereblon (CRBN) ligands and a lenalidomide-linker within its structure, effectively inhibiting cell death in a TSZ-induced model of...
| MW: | 948.05 D |
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ROCK-IN-9
Item number: TGM-T79833-50mg
Description: ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 µM. It demonstrates favorable pharmacokinetic properties in mice, achieving high in vivo exposure and oral bioavailability at low doses [1]. Target: ROCK
| CAS | 2643334-76-1 |
| MW: | 381.4 D |
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