Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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cis-4-Br-2,5-F2-PCPA
Item number: TGM-T60359-100mg
Description: cis-4-Br-2,5-F2-PCPA (S1024) inhibits LSD1 and LSD2 with Ki values of 94 nM and 8.4 µM, respectively. It inhibits LSD1 cell proliferation and increases dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells, particularly where there is aberrant expression of LSD1 in cancer stem cells [1]. Target: Others
| MW: | 248.07 D |
From 1,440.00€
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LSD1/2-IN-3
Item number: TGM-T60360-100mg
Description: LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1) with a Ki value of 11 nM, compared to 7 µM for LSD2. Aberrant expression of LSD1 is found in tumor stem cells, and LSD1/2-IN-1 inhibits LSD1 cell proliferation [1]. Target: Others
| MW: | 248.07 D |
From 1,440.00€
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LSD1/2-IN-4
Item number: TGM-T60361-100mg
Description: LSD1/2-IN-4, a derivative of PCPA, functions as an inhibitor for both lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2), demonstrating K i values of 0.11 µM and 130 µM against LSD1 and LSD2, respectively. This compound is utilized in researching various cancers, notably...
| MW: | 248.07 D |
From 1,440.00€
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LSD1-IN-22
Item number: TGM-T60362-100mg
Description: LSD1-IN-22 is a potent inhibitor of Lysine-specific demethylase 1 (LSD1) with a K_i value of 98 nM, exhibiting anti-proliferative activity against certain cancer cells [1]. Target: Others
| MW: | 248.07 D |
From 1,440.00€
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CD73-IN-2
Item number: TGM-T63128-100mg
Description: CD73-IN-2 is a potent inhibitor of CD73 with an IC50 value of 0.09 nM. Target: Others
| MW: | 477.84 D |
From 1,440.00€
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Glutaminyl cyclases-IN-1
Item number: TGM-T63139-100mg
Description: Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent inhibitor of Glutaminyl cyclases (QC), acting on human QC with an IC50 of 12 nM and on isoQC with an IC50 of 73 nM. It selectively inhibits isoQC, blocks CD47/SIRPalpha interaction, and enhances phagocytosis in THP-1 and U937 macrophages. Target: Others
| MW: | 478.61 D |
From 1,440.00€
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ZLMT-12
Item number: TGM-T63144-100mg
Description: ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 µM) and CDK9 (IC50: 0.002 µM). ZLMT-12 weakly inhibits AChE (IC50: 19.023 µM) and BuChE (IC50: 2.768 µM). ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and...
| MW: | 479.02 D |
From 1,440.00€
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Antifungal agent 16
Item number: TGM-T63157-100mg
Description: Antifungal agent 16 has antimicrobial activity comparable to that of ciprofloxacin and has higher antifungal activity than fluconazole. Target: Others
| MW: | 479.55 D |
From 1,440.00€
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Anticancer agent 28
Item number: TGM-T63159-100mg
Description: Anticancer agent 28 showed good anti-tumour effects in vivo in H22 allograft mice. anticancer agent 28 was 50 times more potent than Oridonin against K562 cells with an IC50 value of 0.09 µM. Target: Others
| MW: | 479.56 D |
From 1,440.00€
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AD011
Item number: TGM-T63160-100mg
Description: AD011 is a dual cACE/NEP inhibitor. AD011 was synthesized via the previously reported C-domain selective ACE inhibitor lenopril-tryptophan. AD011 shows potential to provide potent anti-hypertensive and cardioprotective effects. Target: Others
| MW: | 479.57 D |
From 1,440.00€
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cSPM
Item number: TGM-T63163-100mg
Description: cSPM (Cyclic spermine) is an Abeta42 inhibitor. cSPM inhibits the aggregation of three different peptides, Abeta42, tryptophan and insulin, and reduces cytotoxicity. Target: Others
| MW: | 479.79 D |
From 1,440.00€
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MIF2-IN-1
Item number: TGM-T63169-100mg
Description: MIF2-IN-1 (compound 5d) is a potent MIF2 tautomerase inhibitor (IC50: 1.0 µM) that inhibits the proliferation of non-small cell lung cancer cells by arresting the cell cycle through the MAPK pathway, with potential applications in cancer disease studies. Target: Others
| MW: | 480.5 D |
From 1,440.00€
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