Products from TargetMol

TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.

More information at: www.targetmol.com

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CAM 833

Item number: TGM-T41211-25mg

Description: CAM 833 is an effective positivity inhibitor, which can inhibit the interaction between BRCA2 and RAD51. The Kd of ChimRAD51 protein is 366 nM. CAM 833 inhibited the oligocoagulation of RAD51 and promoted the process of apoptosis in G2/M cells. Target: Others. References: Scott et al (2021) A...

1,440.00€ *

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MD13

Item number: TGM-T41225-25mg

Description: MD13 is a macrophage migration inhibitor (MIF) oriented PROTAC (Ki value: 71 nM). MD13 can be used to study cancer. Target: Others. References: Xiao et al (2021) Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti-proliferative activity in lung cancer cells....

1,440.00€ *

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SIM1

Item number: TGM-T41226-5mg

Description: SIM1 is a potent and selective trivalent PROTAC(R)Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively)....

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CG 428-Neg

Item number: TGM-T41228-5mg

Description: Negative control for CG 428. Target: Others. References: Chen et al (2020) Discovery of first-in-class potent and selective tropomyosin receptor kinase degraders. J.Med.Chem. 63 14562 PMID: 33058680

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MD15

Item number: TGM-T41229-5mg

Description: MD15 is a negative control for MD13. Target: Others

Keywords:

MD15

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LY 379268 disodium salt

Item number: TGM-T41234-10mg

Description: LY 379268 disodium salt is a sodium salt of LY 379268, a highly selective group II mGlu receptor agonist. Target: Others. References: Bond et al (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral...

1,725.00€ *

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Maoecrystal A

Item number: TGM-T4S1980-2mg

Description: Maoecrystal A is a natural compound isolated from the leaves of I. eriocalyx with anti-inflammatory, antioxidant and antibacterial activity. Target: Antioxidant, Antibacterial, Others. Smiles: [H][C@@]12C[C@]3([C@H](OC(C)=O)C1=C)C(=O)[C@@H](O)[C@]1([H])C(C)(C)[C@@]4([H])CC(=O)[C@@]1(CO4)[C@]3([H])CC2

MW:

388.45 D

291.00€ *

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iNOS/PGE2-IN-1

Item number: TGM-T63104-100mg

Description: iNOS/PGE2-IN-1 is an iNOS/PGE2 inhibitor and a potent anti-inflammatory agent. iNOS/PGE2-IN-1 exhibits an inhibitory effect on LPS-induced NO production and has a low ulcerogenic potential. Target: Others

MW:

475.92 D

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Anti-inflammatory agent 6

Item number: TGM-T63107-100mg

Description: Anti-inflammatory agent 6 exhibits anti-inflammatory potential by blocking the phosphorylation of Ikappab kinase alpha/beta (IKKalpha/beta), IkappaBalpha and nuclear factor kB p65 (NF-kappab p65), which are key controllers of inflammation. Target: Others

MW:

476.39 D

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Tubulin polymerization-IN-33

Item number: TGM-T63111-100mg

Description: Tubulin polymerization-IN-33, an [1,2] inhibitor of oxazoloisoindole microtubulin polymerization, is an effective anti-proliferative agent for NCI series cancer cells. Target: Others

MW:

476.52 D

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