Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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CDK7/9 tide
Item number: TGM-T36743-10mg
Description: CDK7/9 tide is a peptide substrate for CDK7 or CDK9[1]. References: Robert T, et, al. Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Front Chem. 2020 Feb 27, 8:147.
From 156.00€
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CDK9 Antagonist-1
Item number: TGM-T36744-100mg
Description: CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 µM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. Target: Others. References: Bian J , et al. Discovery of Wogonin-based...
| Keywords: | CDK9 Antagonist-1 |
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KQMEEEAVRLFIEWLKNGGPSSGAPPPS
Item number: TGM-T36760-10mg
Description: KQMEEEAVRL FIEWLKNGGP SSGAPPPS is a Exendin-4 peptide derivative. Target: Others. References: US20150315260 A1
From 240.00€
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Parathyroid Hormone (1-13) (trifluoroacetate salt)
Item number: TGM-T36767-1mg
Description: Parathyroid hormone (PTH) (1-13) is an N-terminal fragment of PTH (1-34) . Target: Others
232.00€
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Thrombin Receptor Agonist Peptide (trifluoroacetate salt)
Item number: TGM-T36777-1mg
Description: Thrombin receptor agonist peptide (TRAP-14) is a 14-amino acid peptide agonist of the alpha-thrombin receptor. It induces aggregation of washed platelets as well as platelets in citrated and hirudin plasma. TRAP-14 (100 µM) increases the cytosolic calcium concentration in isolated guinea pig pulmonary...
733.00€
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NG 25 (hydrochloride hydrate)
Item number: TGM-T36779-10mg
Description: NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38alpha (IC50s = 56.4, 82.3, and 102...
From 183.00€
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TAK1-IN-2
Item number: TGM-T36782-100mg
Description: TAK1-IN-2 is a potent and selective TAK1 inhibitor with an IC50 of greater than 2 nM [1]. Target: Others. References: Veerman JJN, et, al. Discovery of 2,4-1 H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. ACS Med Chem Lett. 2021 Mar 3,12(4):555-562.
| Keywords: | TAK1-IN-2 |
From 353.00€
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UNC 2399
Item number: TGM-T36799-1mg
Description: Biotinylated UNC 1999 (IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells. Negative control also avilable. Target: Others
253.00€
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AAQ chloride
Item number: TGM-T36803-10mg
Description: Photoswitchable Kv channel blocker (IC50 values are 2 and 64 µM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in...
From 674.00€
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TPC2-A1-N
Item number: TGM-T36805-1mg
Description: TPC2-A1-N is a novel lipophilic, membrane-permeable subtype-selective TPC2 small molecule agonist that activates endogenous TPC2 to moderately increase lysosomal pH in untransfected cells in a time-dependent manner, and can be used to assay the differential function of TPC2 channels in intact cells....
| MW: | 401.17 D |
188.00€
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TPC2-A1-P
Item number: TGM-T36806-100mg
Description: TPC2-A1-P is a potent, membrane-permeable agonist of the two-pore channel 2 (TPC2), exhibiting an EC50 of 10.5 µM. It exerts its effects by mimicking the physiological actions of PI(3,5)P2, and demonstrates greater efficacy in inducing Na2+ mobilization from TPC2 compared to TPC-A1-N. This compound...
| Keywords: | TPC2-A1-P |
From 235.00€
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Estradiol 17-(beta-D-Glucuronide) (sodium salt hydrate)
Item number: TGM-T36807-10mg
Description: Estradiol 17-(beta-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2, Km= 75 µM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In...
From 250.00€
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