Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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KU60019
Item number: TGM-T2474-10mg
Description: Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases. Target: ATM/ATR. Smiles: C[C@H]1CN(CC(=O)Nc2ccc3Sc4c(Cc3c2)cccc4-c2cc(=O)cc(o2)N2CCOCC2)C[C@@H](C)O1. References: Golding SE, et al. Improved ATM...
| Keywords: | KU-60019, KU 60019 |
| CAS | 925701-49-1 |
| MW: | 547.67 D |
From 46.00€
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KU-0063794
Item number: TGM-T2475-100mg
Description: KU-0063794 is a potent and highly specific dual inhibitor of mTORC1 and mTORC2. Target: mTOR. Smiles: COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1C[C@H](C)O[C@H](C)C1)N1CCOCC1. References: García-Martínez JM, et al. Biochem J, 2009, 421(1), 29
| Application: | TORC1/2 inhibitor |
| CAS | 938440-64-3 |
| MW: | 465.54 D |
From 49.00€
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INCB032304
Item number: TGM-T2476-100mg
Description: INCB032304 is an important pharmaceutical intermediate. It can be used in the preparation of Ruxolitinib phosphate (I008849), a janus kinase inhibitor, and in the preparation of Barretinib. Target: Others. Smiles: C(OCC[Si](C)(C)C)N1C=2C(=C(N=CN2)C=3C=NNC3)C=C1
| Keywords: | 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine |
| CAS | 941685-27-4 |
| MW: | 315.45 D |
29.00€
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UNBS5162
Item number: TGM-T2477-100mg
Description: UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Target: CXCR, Autophagy. Smiles: CN(C)CCN1C(=O)c2cccc3cc(NC(N)=O)cc(C1=O)c23
| Keywords: | UNBS 5162 , UNBS-5162 |
| CAS | 956590-23-1 |
| MW: | 326.35 D |
From 32.00€
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Tyrphostin A9
Item number: TGM-T2479-100mg
Description: Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor. Target: EGFR, PDGFR, Influenza Virus, VEGFR. Smiles: CC(C)(C)c1cc(C=C(C#N)C#N)cc(c1O)C(C)(C)C. References: Gazit A, et al. J Med Chem, 1989, 32(10), 2344-2352.
| Keywords: | Tyrphostin 9, Malonoben, RG-50872, AG 17, SF 6847 |
| Application: | EGF receptor kinase inhibitor |
| CAS | 10537-47-0 |
| MW: | 282.38 D |
From 29.00€
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Ricolinostat
Item number: TGM-T2489-100mg
Description: Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. Target: Apoptosis, HDAC. Smiles: ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1. References: Santo L, et al. Blood, 2012, 119(11), 2579-2589.
| Keywords: | ACY-1215, Rocilinostat |
| Application: | Targets histone deacetylase 6 [EC:3.5.1.98] (HDAC6) |
| CAS | 1316214-52-4 |
| MW: | 433.5 D |
From 42.00€
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Osimertinib
Item number: TGM-T2490-100mg
Description: Osimertinib (AZD-9291) is an EGFR third-generation inhibitor that inhibits the T790M resistance mutation produced by second-generation EGFR inhibitors with irreversible and oral activity. Osimertinib has antitumor activity for the treatment of EGFR-mutated non-small-cell lung cancer. Target: EGFR....
| Keywords: | AZD-9291 , Mereletinib |
| Application: | Mutant-selective EGFR inhibitor |
| CAS | 1421373-65-0 |
| MW: | 499.61 D |
From 30.00€
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Perifosine
Item number: TGM-T2492-100mg
Description: Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity. Target: Autophagy, Apoptosis, Akt. Smiles: O(P(OCCCCCCCCC CCCCCCCCC)(=O)[O-])C1CC[N+](C)(C)CC1. References: Vyomesh Patel, et al. Cancer Res, 2002, 62(5), 1401-1409
| Keywords: | D21266, KRX-0401, NSC 639966 |
| CAS | 157716-52-4 |
| MW: | 461.66 D |
From 38.00€
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PD 151746
Item number: TGM-T2493-10mg
Description: PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 µM) over m-calpain (Ki = 5.33 ± 0.77 µM). Its IC50 values are 0.26 ± 0.03 µM (Ki for µ-calpain) and 5.33 ± 0.77 µM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity...
| Application: | Calpain-1 inhibitor |
| CAS | 179461-52-0 |
| MW: | 237.25 D |
From 34.00€
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Cilengitide
Item number: TGM-T2494-100mg
Description: Cilengitide (EMD 121974) is a potent integrin inhibitor for the alphavbeta3/5 receptor (IC50: 4.1/79 nM, in cell-free assays) with approximately 10-fold selectivity against gpIIbIIIa. Target: Apoptosis, Integrin, PD-1/PD-L1, STAT, Autophagy. Smiles:...
| Keywords: | EMD 121974 |
| Application: | Angiogenesis inhibitor, Integrin antagonist |
| CAS | 188968-51-6 |
| MW: | 588.66 D |
From 43.00€
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(Z)-Semaxinib
Item number: TGM-T2496-100mg
Description: (Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 µM), 20-fold more selective for VEGFR over PDGFRbeta, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative with potential antineoplastic activity. Target: VEGFR. Smiles:...
| Keywords: | SU5416 |
| Application: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 194413-58-6 |
| MW: | 238.28 D |
From 49.00€
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MPEP hydrochloride
Item number: TGM-T2497-100mg
Description: MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM). Target: GluR. Smiles: Cl.Cc1cccc(n1)C#Cc1ccccc1. References: Inta Dragos, et al. Neuropharmacology (2012), 62(5-6), 2034-2039.
| Application: | mGlu5a receptor antagonist |
| CAS | 219911-35-0 |
| MW: | 229.7 D |
From 38.00€
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