Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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PROTAC BRD9-binding moiety 5
Item number: TGM-T74256-50mg
Description: PROTAC BRD9-binding moiety 5, a selective binder of BRD9 with an IC50 value of 4.20 µM, is utilized in PROTAC synthesis and exhibits antiproliferative activity against cancer cells [1]. Target: Others
| CAS | 893633-37-9 |
| MW: | 346.39 D |
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PF15
Item number: TGM-T74259-50mg
Description: PF15, a selective FLT3-ITD degrader, serves as a PROTAC (proteolysis targeting chimera) tethering ligands for FLT3 kinase and CRBN. It exhibits a degradation concentration 50 (DC50) of 76.7 nM and notably impedes the proliferation of FLT3-ITD-positive cells. PF15 also reduces phosphorylation levels of...
| CAS | 2892631-70-6 |
| MW: | 855.94 D |
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(R)-V-0219 hydrochloride
Item number: TGM-T74264-2mg
Description: (R)-V-0219 hydrochloride, an enantiomer of V-0219, functions as an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R). It induces calcium fluxes in HEK cells expressing hGLP-1R [1], highlighting its biochemical activity and potential therapeutic applications. Target: Others
| MW: | 446.89 D |
56.00€
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(S)-V-0219 hydrochloride
Item number: TGM-T74265-50mg
Description: (S)-V-0219 hydrochloride, an enantiomer of V-0219, serves as an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R), enhancing calcium fluxes in HEK cells that stably express hGLP-1R. Additionally, it effectively reduces high glucose levels and suppresses feeding behavior in...
| MW: | 446.89 D |
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TRIM24/BRPF1-IN-2
Item number: TGM-T74271-50mg
Description: TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1 with IC50 values of 0.98 µM for TRIM24 and 1.16 µM for BRPF1, exhibiting strong binding affinity to the bromodomains of TRIM24/BRPF1, making it a valuable tool for prostate cancer research [1]. Target: Others
| MW: | 386.46 D |
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LEB-03-145
Item number: TGM-T74274-50mg
Description: LEB-03-145 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker [1] . Target: Others
| MW: | 845.99 D |
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LEB-03-144
Item number: TGM-T74275-50mg
Description: LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells [1] . Target: Others
| MW: | 817.94 D |
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LEB-03-153
Item number: TGM-T74276-50mg
Description: LEB-03-153 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker [1] . Target: Others
| MW: | 760.84 D |
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NJH-2-056
Item number: TGM-T74277-50mg
Description: NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research [1] . Target: PROTACs
| MW: | 782.79 D |
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HSP70-IN-3
Item number: TGM-T74278-50mg
Description: HSP70-IN-3, a potent inhibitor of HSP70 with IC50 values of 1.1 µM in ASZ001 cells and 1.9 µM in C3H10T1/2 cells, exhibits anti-Hedgehog (Hh) signaling and anti-proliferative activities. Furthermore, it reduces the expression of the oncogenic transcription factor GLI1 [1]. Target: Others
| MW: | 883.23 D |
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16:0 TAP
Item number: TGM-T74290-100mg
Description: 16:0 TAP, a lipid compound, is utilized in the preparation of giant unilamellar vesicles for agent delivery [1]. Target: Others
| CAS | 139984-36-4 |
| MW: | 646.47 D |
From 168.00€
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18:0 DAP
Item number: TGM-T74291-50mg
Description: 18:0 DAP can be utilized in the formulation of lipid nanoparticles (LNPs) that encapsulate mRNA within their core [1]. Target: Others
| CAS | 121315-93-3 |
| MW: | 652.09 D |
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