Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Firategrast
Item number: TGM-TQ0291-100mg
Description: Firategrast (SB 683699) is an orally active and specific alpha4beta1/alpha4beta7 integrin antagonist that reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity. It is used in relapsing-remitting multiple sclerosis, associated with...
| Keywords: | SB 683699 |
| Application: | Targets integrin alpha 4 (ITGA4, CD49d) |
| CAS | 402567-16-2 |
| MW: | 499.5 D |
From 38.00€
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Grapiprant
Item number: TGM-TQ0292-100mg
Description: Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). Target: Prostaglandin Receptor. Smiles: CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1. References: Vito VD, et al....
| Keywords: | AAT-007, CJ-023423, RQ-00000007 |
| Application: | Targets prostaglandin E receptor 4 (PTGER4) |
| CAS | 415903-37-6 |
| MW: | 491.61 D |
From 30.00€
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AV-412 free base
Item number: TGM-TQ0293-2mg
Description: AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2). Target: EGFR. Smiles: CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C. References: Suzuki T, et al. Pharmacological characterization of MP-412...
| Keywords: | MP-412 free base |
| Application: | EGFR / ErbB2 inhibitor |
| CAS | 451492-95-8 |
| MW: | 507 D |
62.00€
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Coumestrol
Item number: TGM-TQ0295-10mg
Description: Coumestrol that existed in soybean products suppresses the proliferation of ES2 cells (IC50: 50 µM). It exhibits activities against neurological disorders, cancers and autoimmune diseases. Target: Estrogen Receptor/ERR. Smiles: Oc1ccc2c(c1)oc1c2c(=O)oc2cc(O)ccc12. References: Zafar A, et al. Cytotoxic...
| Application: | 17-beta-hydroxysteroid oxidoreductase inhibitor |
| CAS | 479-13-0 |
| MW: | 268.22 D |
From 39.00€
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N-Nornuciferine
Item number: TGM-TQ0296-20mg
Description: N-Nornuciferine, an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 µM, Ki: 2.34 µM). Target: P450. Smiles: COc1cc2CCN[C@@H]3Cc4ccccc4-c(c1OC)c23. References: Ye LH, et al. Identification and characterization of potent CYP2D6 inhibitors in lotus leaves. J Ethnopharmacol. 2014...
| Application: | Alkaloid, cholinesterase inhibitory agent |
| CAS | 4846-19-9 |
| MW: | 281.35 D |
755.00€
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N-Nornuciferine hydrochloride(4846-19-9 free base)
Item number: TGM-TQ0296L-100mg
Description: N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) is an aporphine alkaloid in lotus leaf, significantly inhibits CYP2D6 (IC50: 3.76 µM, Ki: 2.34 µM). Target: P450. Smiles: Cl.[H][C@]12Cc3ccccc3-c3c(OC)c(OC)cc(CCN1)c23. References: Ye LH, et al. Identification and...
| Keywords: | N-Nornuciferine hydrochloride |
| MW: | 317.81 D |
From 125.00€
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Fagomine
Item number: TGM-TQ0298-1mg
Description: Fagomine (D-Fagomine) is a mild glycosidase inhibitor, an analog of 1-deoxynojirimycin (DNJ) with hypoglycemic activity, and Fagomine reduces intracellular reactive oxygen species (ROS) production and malondialdehyde (MDA) levels. Target: glycosidase, ROS. Smiles: OC[C@H]1NCC[C@@H](O)[C@@H]1O....
| Keywords: | D-Fagomine |
| CAS | 53185-12-9 |
| MW: | 147.17 D |
188.00€
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Exalamide
Item number: TGM-TQ0299-2mg
Description: Exalamide (2-(Hexyloxy)benzamide) is an aromatic amide with antifungal activity used in the study of dermatophytes. Target: Antifungal. Smiles: CCCCCCOc1ccccc1C(N)=O. References: T Kusunoki, et al. Comparison of the in vitro antifungal activities of clotrimazole, miconazole, econazole and exalamide...
| Keywords: | 2-(Hexyloxy)benzamide |
| Application: | Antifungal |
| CAS | 53370-90-4 |
| MW: | 221.3 D |
141.00€
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Conduritol B epoxide
Item number: TGM-TQ0300-100mg
Description: Conduritol B epoxide is an irreversible inhibitor of beta-glucosidase (GCase). Target: Glucosidase. Smiles: O[C@H]1[C@H]2O[C@H]2[C@H](O)[C@@H](O)[C@@H]1O. References: Liou B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet....
| Application: | Irreversible glucocerebrosidase inhibitor |
| CAS | 6090-95-5 |
| MW: | 162.14 D |
From 39.00€
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Kuwanon A
Item number: TGM-TQ0301-1mg
Description: Kuwanon A inhibits nitric oxide production (IC50: 10.5 µM). Kuwanon A is a flavone derivative isolated from Morus alba L. Target: NO Synthase. Smiles: CC(C)=CCc1c(oc2cc(O)cc(O)c2c1=O)-c1ccc(O)c2C=CC(C)(C)Oc12. References: Yang ZG, et al. Inhibitory effects of constituents from Morus alba var....
| CAS | 62949-77-3 |
| MW: | 420.45 D |
From 47.00€
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Thapsigargin
Item number: TGM-TQ0302-1mg
Description: Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic...
| Application: | SERCA inhibitor, Ca2+ releaser |
| CAS | 67526-95-8 |
| MW: | 650.75 D |
From 77.00€
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MLN120B
Item number: TGM-TQ0306-100mg
Description: MLN120B is a selective and ATP competitive IKKbeta inhibitor (IC50: 60 nM). Target: IkappaB/IKK. Smiles: COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C. References: Hideshima T, et all. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer...
| Application: | IKKbeta inhibitor |
| CAS | 783348-36-7 |
| MW: | 366.8 D |
From 43.00€
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