Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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BAR502
Item number: TGM-TQ0252-100mg
Description: BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 µM and 2 µM). Target: GPCR19, Autophagy, FXR. Smiles: CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCO)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12. References: Cipriani S, et al. Impaired Itching Perception in Murine Models of Cholestasis Is...
| Application: | GPBAR1 /FXR dual agonist |
| CAS | 1612191-86-2 |
| MW: | 392.62 D |
From 39.00€
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PLX51107
Item number: TGM-TQ0253-100mg
Description: PLX51107 is a potent and selective BET inhibitor with Kds of 1.6, 2.1, 1.7, and 5 nM for BRD2-BD1, BRD3-BD1, BRD4-BD1, and BRDT-BD1, respectively. Target: Epigenetic Reader Domain. Smiles: C[C@@H](c1ccccn1)n1cc(-c2ccc(cc2)C(O)=O)c2ncc(cc12)-c1c(C)noc1C. References: Ozer HG, et al. BRD4 Profiling...
| Application: | BET family protein inhibitor |
| CAS | 1627929-55-8 |
| MW: | 438.48 D |
From 48.00€
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Olafertinib
Item number: TGM-TQ0255-100mg
Description: Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC. Target: EGFR. Smiles: OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F. References: Xiangping Qian, et al. Abstract 2078: CK-101 (RX518), a...
| Keywords: | RX-518, EGFR-IN-3, CK-101 |
| Application: | EGFR inhibitor |
| CAS | 1660963-42-7 |
| MW: | 530.57 D |
From 39.00€
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FGFR4-IN-1
Item number: TGM-TQ0256-10mg
Description: FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM). Target: FGFR. Smiles: COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc23)ncc1C#N. References: Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO 2015059668 A1
| Application: | FGFR-4 inhibitor |
| CAS | 1708971-72-5 |
| MW: | 493.52 D |
From 42.00€
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Corynoxine B
Item number: TGM-TQ0258-1mg
Description: Corynoxine B is a Beclin-1-dependent autophagy inducer. It is an natural alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese). Target: Autophagy. Smiles: [H][C@@]12C[C@@H]([C@H](CC)CN1CC[C@]21C(=O)Nc2ccccc12)C(=C/OC)\C(=O)OC. References: Song JX, et al. HMGB1 is involved in...
| CAS | 17391-18-3 |
| MW: | 384.47 D |
From 87.00€
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Atrasentan
Item number: TGM-TQ0259-10mg
Description: Atrasentan (ABT-627) (ABT-627) is an endothelin receptor antagonist (IC50: 0.0551 nM for ETA). Target: Endothelin Receptor. Smiles: C(O)(=O)[C@H]1[C@@H](N(CC(N(CCCC)CCCC)=O)C[C@@H]1C=2C=C3C(=CC2)OCO3)C4=CC=C(OC)C=C4. References: Yuyama H, et al. Superiority of YM598 over atrasentan as a selective...
| Keywords: | ABT-627, (+)-A 127722, A-147627 |
| CAS | 173937-91-2 |
| MW: | 510.62 D |
From 39.00€
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Cerulenin
Item number: TGM-TQ0260-1mg
Description: Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus. Target: Antibiotic, Antifungal, Fatty Acid Synthase. Smiles: [H][C@]1(O[C@]1([H])C(=O)CC\C=C\C\C=C\C)C(N)=O. References: Tian D, et al. Overexpression of steroidogenic acute regulatory...
| MW: | 223.27 D |
88.00€
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EPZ031686
Item number: TGM-TQ0263-100mg
Description: EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer. Target: Histone Methyltransferase. Smiles: FC(F)(F)CCCN1CCC(CS(=O)(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)NC(=O)c2cc3CC(=O)Nc3cc2Cl)CC1. References: Mitchell LH et al. Novel Oxindole Sulfonamides...
| Keywords: | EPZ-031686 |
| CAS | 1808011-22-4 |
| MW: | 591.09 D |
From 106.00€
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Nigakinone
Item number: TGM-TQ0264-10mg
Description: Nigakinone, isolated from Kumu, is an alkaloid with the pharmacological activity. Target: Others. Smiles: COc1c(O)c(=O)n2c3ccccc3c3ccnc1c23. References: Wang N, et al. Quality Assessment of Kumu Injection, a Traditional Chinese Medicine Preparation, Using HPLC Combined with Chemometric Methods and...
| CAS | 18110-86-6 |
| MW: | 266.25 D |
From 53.00€
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Indolelactic acid
Item number: TGM-TQ0265-10mg
Description: Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures. Target: Endogenous Metabolite. Smiles: OC(Cc1c[nH]c2ccccc12)C(O)=O. References: Francisco García-Tabares, et al. Production of 3-indoleacetic acid and 3-indolelactic acid in Azotobacter vinelandii cultures supplemented...
| CAS | 1821-52-9 |
| MW: | 205.21 D |
From 39.00€
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MSC2530818
Item number: TGM-TQ0266-100mg
Description: MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM). Target: CDK. Smiles: Cc1n[nH]c2ncc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1. References: Czodrowski P, et al. Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by...
| Application: | CDK8 inhibitor |
| CAS | 1883423-59-3 |
| MW: | 340.81 D |
From 57.00€
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Endomorphin 1
Item number: TGM-TQ0267-10mg
Description: Endomorphin 1 is a high affinity and selective agonist of the µ-opioid receptor and displays reasonable affinities for kappa3 binding sites (Ki: 20~30 nM). Target: Opioid Receptor. Smiles: N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O. References:...
| Keywords: | Endomorphin-1 |
| CAS | 189388-22-5 |
| MW: | 610.7 D |
From 43.00€
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