Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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NVP-CGM097
Item number: TGM-TQ0231-100mg
Description: NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2). Target: E1/E2/E3 Enzyme, Mdm2. Smiles: COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(cc1)N(C)C[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1. References: Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative...
| Keywords: | CGM097 |
| Application: | MDM2-p53 protein-protein interaction inhibitor |
| CAS | 1313363-54-0 |
| MW: | 659.26 D |
From 75.00€
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UNC0646
Item number: TGM-TQ0232-100mg
Description: UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) and exhibits low cellular toxicity (EC50: 4.7 µM in MCF7...
| Keywords: | UNC 0646 |
| Application: | Potent, selective EHMT1 / EHMT2 inhibitor |
| CAS | 1320288-17-2 |
| MW: | 621.9 D |
From 55.00€
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Traxoprodil
Item number: TGM-TQ0233-10mg
Description: Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). Target: NMDAR, iGluR. Smiles: OC1(CCN([C@H]([C@@H](O)C2=CC=C(O)C=C2)C)CC1)C3=CC=CC=C3. References: Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent...
| Keywords: | CP101606 |
| CAS | 134234-12-1 |
| MW: | 327.42 D |
From 45.00€
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Traxoprodil Mesylate
Item number: TGM-TQ0233L-100mg
Description: Traxoprodil Mesylate is a potent noncompetitive N-methyl-D-aspartate (NMDA) receptors antagonist and has selective for the NR2B subunit. Target: Others. Smiles: S(C)(=O)(=O)O.OC1(CCN([C@H]([C@@H](O)C2=CC=C(O)C=C2)C)CC1)C3=CC=CC=C3. References: DePoy LM, Zimmermann KS, Marvar PJ, Gourley SL. Induction...
| CAS | 188591-67-5 |
| MW: | 423.52 D |
From 1,440.00€
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Epoxymicheliolide
Item number: TGM-TQ0234-100mg
Description: Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and several other natural products. It functions as a plant metabolite. Target: Others. Smiles: [H][C@@]12CC[C@]3(C)O[C@@]33CC[C@@](C)(O)[C@]3([H])[C@@]1([H])OC(=O)C2=C. References: Qi Z, et al. Study of effects of micheliolide...
| Keywords: | 1beta,10beta-Epoxymicheliolide |
| CAS | 1343403-10-0 |
| MW: | 264.32 D |
Please request pricing for this article.
Tirabrutinib
Item number: TGM-TQ0236-100mg
Description: Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of...
| Keywords: | ONO-4059 , GS-4059 , Velexbru |
| Application: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1351636-18-4 |
| MW: | 454.48 D |
From 29.00€
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Lanabecestat
Item number: TGM-TQ0238-1mg
Description: Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier, Lanabecestat can be used for the study of neurological diseases like Alzheimer's disease. Target: BACE. Smiles:...
| Keywords: | AZD3293, LY3314814 |
| Application: | Targets beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] (BACE1) |
| CAS | 1383982-64-6 |
| MW: | 412.53 D |
141.00€
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PF-06291874
Item number: TGM-TQ0239-10mg
Description: PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor. Target: Glucagon Receptor. Smiles: CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O. References: Guzman-Perez A et al. The...
| Keywords: | Glucagon receptor antagonists-4 |
| Application: | GCGR antagonist |
| CAS | 1393124-08-7 |
| MW: | 503.51 D |
From 52.00€
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6"-O-Apiosyl-5-O-Methylvisammioside
Item number: TGM-TQ0240-10mg
Description: 6"-O-Apiosyl-5-O-Methylvisammioside, a component of the traditional Chinese medicine Kang-Jing, promotes blood circulation, clears collaterals, disperses wind, and relieves pain. Target: Others. Smiles:...
| CAS | 139446-82-5 |
| MW: | 584.57 D |
Please request pricing for this article.
TUG-770
Item number: TGM-TQ0241-100mg
Description: TUG-770 is a GPR40/FFA1 agonist with potential anti-inflammatory activity.TUG-770 can be used to study type 2 diabetes, dementia, and Alzheimer's disease. Target: GPR. Smiles: OC(=O)CCc1ccc(cc1F)C#Cc1ccccc1CC#N. References: Christiansen E, et al. Discovery of TUG-770: A Highly Potent Free Fatty Acid...
| Keywords: | TUG 770, TUG770 |
| Application: | GPR40 agonist |
| CAS | 1402601-82-4 |
| MW: | 307.32 D |
From 55.00€
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Fenebrutinib
Item number: TGM-TQ0242-10mg
Description: Fenebrutinib (GDC-0853) is a selective and noncovalent inhibitor of Bruton's tyrosine kinase (Btk) with a Ki of 0.91 nM. Target: BTK. Smiles: C[C@H]1CN(CCN1c1ccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)nc1)C1COC1. References: Erickson RI , et al. Bruton's Tyrosine Kinase Small Molecule...
| Keywords: | GDC-0853 |
| Application: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| CAS | 1434048-34-6 |
| MW: | 664.8 D |
From 35.00€
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Fenebrutinib HCl
Item number: TGM-TQ0242L-25mg
Description: Fenebrutinib is orally available inhibitor of Bruton's tyrosine kinase (BTK) with antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated...
| Keywords: | GDC 0853, RG 7845, GDC-0853, GDC0853, RG7845, RG-7845 |
| CAS | 2128304-54-9 |
| MW: | 701.27 D |
1,440.00€
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