Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Chebulagic acid
Item number: TGM-TQ0180-100mg
Description: Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor. Target: Lipoxygenase, SARS-CoV, COX, Influenza Virus. Smiles:...
| CAS | 23094-71-5 |
| MW: | 954.66 D |
From 68.00€
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Resatorvid
Item number: TGM-TQ0181-100mg
Description: Resatorvid (TAK-242), a selective Toll-like receptor 4 (TLR4) inhibitor, binds directly to Cys747 to prevent TLR4-TIRAP interaction, thereby blocking downstream signaling. Resatorvid exhibits antitumor, anti-inflammatory, and neuroprotective activities. Target: Autophagy, TLR, Interleukin, TNF....
| Keywords: | TAK-242, CLI-095 |
| Application: | TLR4 adaptor binding inhibitor |
| CAS | 243984-11-4 |
| MW: | 361.82 D |
From 43.00€
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MK-0812
Item number: TGM-TQ0182-10mg
Description: MK-0812 is an effective and specific CCR2 antagonist. Target: CCR. Smiles: [H][C@]1(CC[C@](C1)(C(C)C)C(=O)N1CCc2ncc(cc2C1)C(F)(F)F)N[C@@]1([H])CCOC[C@@]1([H])OC. References: Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a...
| Application: | CCR2 antagonist |
| CAS | 624733-88-6 |
| MW: | 469.54 D |
From 95.00€
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Narciclasine
Item number: TGM-TQ0183-10mg
Description: Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity. Target: ROCK. Smiles: [H][C@@]12NC(=O)c3c(O)c4OCOc4cc3C1=C[C@H](O)[C@@H](O)[C@H]2O. References: Lefranc F, et al. Narciclasine, a plant growth...
| Keywords: | Lycoricidinol |
| CAS | 29477-83-6 |
| MW: | 307.26 D |
From 91.00€
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Chebulinic acid
Item number: TGM-TQ0184-100mg
Description: Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. Target: DNA/RNA Synthesis, ATPase, Proton pump, Antibacterial, TGF-beta/Smad. Smiles:...
| Application: | Bioactive ellagitannin, PTPN9 / PTPN11 inhibitor |
| CAS | 18942-26-2 |
| MW: | 956.68 D |
From 64.00€
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14-Deoxy-11,12-didehydroandrographolide
Item number: TGM-TQ0185-100mg
Description: 14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-kappaB activation. Target: NF-kappaB. Smiles: CC1(CO)C(O)CCC2(C)C(CCC3=CCOC3=O)C(=C)CCC12. References: Guan SP, et al. Protective role of...
| Keywords: | 14-dehydro Andrographolide, AP10 |
| CAS | 42895-58-9 |
| MW: | 332.43 D |
From 59.00€
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Ko 143
Item number: TGM-TQ0186-100mg
Description: Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2, BCRP). Target: ABC Transporter, BCRP. Smiles: COc1ccc2c3C[C@@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC4=O. References: Weidner LD, et al. The Inhibitor Ko143 Is Not Specific for ABCG2. J Pharmacol...
| MW: | 469.57 D |
From 38.00€
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SR-3677
Item number: TGM-TQ0187-10mg
Description: SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). Target: ROCK, Autophagy. Smiles: CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccccc2O1)-c1cn[nH]c1. References: Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase...
| Application: | ROCK inhibitor |
| CAS | 1072959-67-1 |
| MW: | 408.45 D |
From 30.00€
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D-Xylulose
Item number: TGM-TQ0190-1mg
Description: D-Xylulose is converted from xylitol by the enzyme NAD+-linked xylitol dehydrogenase in the glucuronate pathway, the most important xylitol-handling metabolic pathway in mammals. Target: Others, Endogenous Metabolite. Smiles: [C@H]([C@@H](CO)O)(C(CO)=O)O. References: Jojanneke H J Huck, et al....
| CAS | 551-84-8 |
| MW: | 150.13 D |
From 78.00€
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Dihydromethysticin
Item number: TGM-TQ0191-100mg
Description: Dihydromethysticin ((+)-Dihydromethysticin) is a kavalactone found in Piper methysticum. It has marked activity on the induction of CYP3A23. Target: Cytochromes P450. Smiles: COC1=CC(=O)O[C@@H](CCc2ccc3OCOc3c2)C1. References: Sarris J, et al. Kava: a comprehensive review of efficacy, safety, and...
| Keywords: | (+)-Dihydromethysticin |
| MW: | 276.28 D |
From 65.00€
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Senecionine
Item number: TGM-TQ0192-100mg
Description: Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist. Target: Others. Smiles: C\C=C1\C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@@H]23. References: D S Griffin, et al. Effects of the Pyrrolizidine Alkaloid...
| Keywords: | Aureine, Senecionan-11,16-dione, 12-hydroxy-, Senecionin |
| CAS | 130-01-8 |
| MW: | 335.39 D |
From 57.00€
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N2,N2-Dimethylguanosine
Item number: TGM-TQ0193-100mg
Description: N2,N2-Dimethylguanosine, a urinary nucleoside, exhibits significantly higher mean levels in patients with colorectal cancer compared to those with intestinal villous adenoma or healthy adults. Target: Endogenous Metabolite. Smiles: CN(C)c1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O....
| CAS | 2140-67-2 |
| MW: | 311.29 D |
From 31.00€
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