Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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TNF Protease Inhibitor 2
Item number: TGM-TQ0129-100mg
Description: TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 µM), tumour necrosis factoralpha-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM). Target: MMP. Smiles: CC(C)CC(CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C. References: Kruse MN, et al. Human meprin alpha and beta...
| Keywords: | TAPI-2 |
| Application: | TNF Protease inhibitor |
| CAS | 187034-31-7 |
| MW: | 415.53 D |
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CP-809101
Item number: TGM-TQ0130-10mg
Description: CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). Target: 5-HT Receptor. Smiles: O(CC1=CC(Cl)=CC=C1)C=2N=C(C=NC2)N3CCNCC3. References: Higgins GA, Silenieks LB, Lau W, et al. Evaluation of chemically diverse 5-HT2C receptor...
| Application: | Potent 5-HT2C receptor agonist |
| CAS | 479683-64-2 |
| MW: | 304.77 D |
From 318.00€
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Rocaglamide
Item number: TGM-TQ0131-1mg
Description: Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-kappaB activation in T-cells. Target: NF-kappaB, PERK, HSP. Smiles:...
| Keywords: | Rocaglamide A, Roc-A |
| Application: | Apoptosis inducer, TNF alpha inhibitor |
| CAS | 84573-16-0 |
| MW: | 505.56 D |
195.00€
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A 419259 trihydrochloride
Item number: TGM-TQ0132-100mg
Description: A 419259 trihydrochloride (RK 20449 trihydrochloride) is an Src family kinases inhibitor (IC50s: 9 nM, 3 nM and 3 nM for Src, Lck and Lyn). Target: Apoptosis, Src. Smiles: Cl.Cl.Cl.CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12. References: Wilson MB, et al. Selective...
| Keywords: | RK 20449 trihydrochloride |
| Application: | Src family kinase inhibitor |
| CAS | 1435934-25-0 |
| MW: | 592 D |
From 46.00€
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Amifostine thiol dihydrochloride
Item number: TGM-TQ0133-10mg
Description: Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs. Target: p53. Smiles: Cl.Cl.NCCCNCCS. References: Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53...
| Keywords: | WR 1065 |
| CAS | 14653-77-1 |
| MW: | 207.165 D |
From 30.00€
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Podocarpusflavone A
Item number: TGM-TQ0134-10mg
Description: Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7. Target: STAT, Topoisomerase. Smiles: COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(=O)c4c(O)cc(O)cc4o3)c2o1. References: Pen-Ho Yeh et al. Naturally Occurring...
| CAS | 22136-74-9 |
| MW: | 552.48 D |
From 76.00€
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3,4-Dihydroxymandelic acid
Item number: TGM-TQ0135-100mg
Description: 3,4-Dihydroxymandelic acid exists in all living organisms, ranging from bacteria to humans. Within humans, 3,4-dihydroxymandelic acid participates in a number of enzymatic reactions. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine. Target: Endogenous Metabolite. Smiles:...
| Application: | Norepinephrine active metabolite |
| CAS | 775-01-9 |
| MW: | 184.15 D |
From 48.00€
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GR79236
Item number: TGM-TQ0136-2mg
Description: GR79236 is an effective and selective adenosine A1 receptor agonist (Ki: 3.1 nM) that has analgesic and anti-inflammatory actions. Target: Adenosine Receptor. Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@H]3CCC[C@@H]3O)ncnc12. References: Sneyd JR, et al. Multicentre evaluation of the adenosine...
| Keywords: | GR 79236 |
| Application: | Selective adenosine receptor A1 agonist |
| CAS | 124555-18-6 |
| MW: | 351.36 D |
47.00€
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A-484954
Item number: TGM-TQ0137-100mg
Description: A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor. Target: CaMK, Parasite, Autophagy. Smiles: CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O. References: Chen Z, et al. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of...
| Keywords: | A 484954 |
| Application: | ATP-competitive eukaryotic elongation factor-2 kinase (eEF-2K) inhibitor |
| CAS | 142557-61-7 |
| MW: | 289.29 D |
From 35.00€
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VU 0240551
Item number: TGM-TQ0139-100mg
Description: VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG. Target: Calcium Channel, HER, Potassium Channel. Smiles: S(CC(NC=1SC=C(C)N1)=O)C2=CC=C(N=N2)C3=CC=CC=C3. References: Delpire E, et al....
| Keywords: | N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, VU0240551-2-D4 |
| Application: | KCC2 inhibitor |
| CAS | 893990-34-6 |
| MW: | 342.44 D |
From 30.00€
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Sumanirole maleate
Item number: TGM-TQ0140-2mg
Description: Sumanirole maleate (U-95666E) is a highly selective full agonist of the D2 receptor (ED50: 46 nM). Target: Dopamine Receptor. Smiles: OC(=O)\C=C/C(O)=O.CN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23. References: Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E from D-Phenylalanine...
| Keywords: | U-95666E, PNU-95666 |
| Application: | Dopamine receptor D2 agonist |
| CAS | 179386-44-8 |
| MW: | 319.31 D |
66.00€
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10-Oxo Docetaxel
Item number: TGM-TQ0142-10mg
Description: 10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties. Target: Others. Smiles: [H][C@@]12C[C@H](O)[C@@]3(C)C(=O)C(=O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1
| Keywords: | Docetaxel Impurity 1 |
| CAS | 167074-97-7 |
| MW: | 805.874 D |
From 848.00€
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