Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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CLM3
Item number: TGM-T200080-100mg
Description: CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition...
| MW: | 343.43 D |
From 1,440.00€
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KRASG12C IN-13
Item number: TGM-T200083-100mg
Description: KRASG12C IN-13 (LY3499446), a potent inhibitor of KRAS G12C, shows potential in the study of advanced solid tumors, specifically non-small cell lung cancer and colorectal cancer. Target: Ras, Kras, Others. Smiles: O=C(C=C)N1CCN(C2=NC=NC3=C(F)C(=C(Cl)C=C32)C=4C=CC(F)=C5SC(=NC54)N)CC1
| MW: | 486.93 D |
From 2,181.00€
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ES-072
Item number: TGM-T200087-100mg
Description: ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3alpha, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin...
| MW: | 528.53 D |
From 1,440.00€
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Nafithromycin
Item number: TGM-T200102-10mg
Description: Nafithromycin (WCK 4873) serves as an orally administered antibiotic effective against community-acquired pneumonia organisms such as Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Methicillin-susceptible Staphylococcus aureus. It displays a minimum inhibitory concentration...
| Keywords: | WCK 4873 |
| MW: | 859.04 D |
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13-Hydroxy-9-octadecenoic acid
Item number: TGM-T200103-100mg
Description: 13-Hydroxy-9-octadecenoic acid, a hydroxy unsaturated fatty acid (HUFA), exhibits anti-fungal activity. Smiles: O=C(O)CCCCCCCC=CCCC(O)CCCCC
| MW: | 298.46 D |
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WK88-1
Item number: TGM-T200115-100mg
Description: WK88-1, an inhibitor of Hsp90, effectively induces the degradation of various oncogenic signaling molecules, including EGFR, ErbB2, and ErbB3, in the gefitinib-resistant H1975 cell line. This leads to subsequent growth arrest and apoptosis. Target: HSP, Apoptosis. Smiles:...
| MW: | 502.64 D |
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4-Amino-3-bromobenzoic acid
Item number: TGM-T200120-10g
Smiles: O=C(C1=CC=C(C(Br)=C1)N)O
| MW: | 216.032 D |
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P-gp inhibitor 25
Item number: TGM-T200121-100mg
Description: P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy. Smiles: O(C)C=1C=C2C3=C(OC2=CC1OC)CN(C(/C=C/C4=CC=C(NC(=O)C5=C(NC(=O)C6=CC7=C(N=C6)C=CC=C7)C=C(OC)C(OC)=C5)C=C4)=O)CC3
| MW: | 712.75 D |
From 2,579.00€
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Enzomenib
Item number: TGM-T200130-100mg
Description: Enzomenib (DSP5336), a menin protein inhibitor encoded by the multiple endocrine neoplasia (MEN) gene, blocks the interaction between menin protein and mixed lineage leukemia (MLL) fusion proteins. This compound is utilized in researching hematological malignancies. Target: Others. Smiles:...
| Keywords: | DSP-5336 , DSP5336 |
| MW: | 590.73 D |
From 1,440.00€
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TAAR1 agonist 2
Item number: TGM-T200140-10mg
Description: TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching...
| MW: | 149.19 D |
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GTCpFE
Item number: TGM-T200141-100mg
Description: GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKalpha/beta in the NF-kappaB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of...
| MW: | 412.39 D |
From 1,440.00€
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Diphenyl(p-tolyl)phosphine
Item number: TGM-T200154-10g
Smiles: CC(C=C1)=CC=C1P(C2=CC=CC=C2)C3=CC=CC=C3
| MW: | 276.312 D |
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