Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Astressin 2B
Item number: TGM-TP2095-500ug
Description: Potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist (IC50 values are 1.3 and > 500 nM for CRF2 and CRF1 respectively). Antagonizes CRF2-mediated inhibition of gastric emptying. References: Rivier et al (2002) Potent and long-acting cortico. releasing factor (CRF) receptor 2...
| MW: | 4041.69 D |
1,858.00€
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[Ala1,3,11,15]-Endothelin
Item number: TGM-TP2099-5mg
Description: Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively). References: Nakamichi et al (1992) Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123...
| CAS | 121204-87-3 |
| MW: | 2368 D |
475.00€
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Z-VRPR-FMK trifluoroacetate salt
Item number: TGM-TP2101-100mg
Description: Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable. References: Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272...
| MW: | 790.81 D |
Please request pricing for this article.
WL 47 - dimer
Item number: TGM-TP2102-10mg
Description: High affinity caveolin-1 (CAV1) ligand (Kd = 23 nM), disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL. References: Gilliam et al (2016) Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J.Med.Chem. 59 4019 PMID:
| MW: | 1844.3 D |
315.00€
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TAPI 0
Item number: TGM-TP2107-1mg
Description: ADAM-17 (TACE) and MMP inhibitor, attenuates TNF-alpha processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth. References: Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting...
| CAS | 163958-73-4 |
| MW: | 456.54 D |
1,222.00€
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TAPI 2
Item number: TGM-TP2108-1mg
Description: ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-alpha from cell membranes. References: Moss et al (2007) Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for...
| CAS | 689284-12-6 |
| MW: | 415.54 D |
1,222.00€
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Tertiapin LQ
Item number: TGM-TP2113-10mg
Description: Blocker of Kir1.1 channels, displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Derivative of tertiapin-Q. References: Ramu et al (2008) Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+...
| MW: | 2428.03 D |
475.00€
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Tertiapin-Q acetate
Item number: TGM-TP2114L-100mg
Description: Tertiapin-Q acetate is a bee toxin derivative that inhibits BK-type K(+) channels in a concentration-dependent manner and inhibits efflux to K(+). Target: Potassium Channel. Smiles:...
| Keywords: | Tertiapin-Q acetate(910044-56-3 Free base) |
| MW: | 2512.06 D |
From 139.00€
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SAH-EZH2
Item number: TGM-TP2115-5mg
Description: EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line. References: Kim et al (2013) Targeted disruption of the EZH2-EED complex inhibits...
| CAS | 1453222-26-8 |
| MW: | 3432.05 D |
1,320.00€
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Sarafotoxin S6c
Item number: TGM-TP2120-100ug
Description: Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively). References: Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905...
| MW: | 2516 D |
885.00€
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Seglitide
Item number: TGM-TP2122-1mg
Description: Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5). References: Hoyer et al (1994) Molecular pharmacology of somatostatin receptors. Naunyn...
| CAS | 81377-02-8 |
| MW: | 808.98 D |
220.00€
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Somatostatin 1-28
Item number: TGM-TP2124-500ug
Description: Somatostatin receptor agonist, derived from the post-translational cleavage of prosomatostatin. References: Panetta et al (1994) Molecular cloning, functional characterization and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for...
| MW: | 3149 D |
1,355.00€
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