Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Acein
Item number: TGM-TP1920-1mg
Description: Acein is a High affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Exhibits no significant effect on ACE enzymatic activity up to 500 nM concentration. Potentiates NMDA + D-serine-induced dopamine release from striatal slices in vitro and the striatum in vivo. References: Neasta et al...
| MW: | 932.5 D |
102.00€
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Saralasin
Item number: TGM-TP1929-5mg
Description: Competitive non-selective angiotensin II antagonist. References: Steinhausen et al (1986) Angiotensin II control of the renal microcirculation: effect of blockade by saralasin. Kidney Int. 30 56 PMID:
| CAS | 34273-10-4 |
| MW: | 912 D |
96.00€
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
Item number: TGM-TP1931-1mg
Description: Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM), diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth...
| CAS | 96736-12-8 |
| MW: | 1516.85 D |
135.00€
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pep2-AVKI
Item number: TGM-TP1942-2mg
Description: pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression...
| CAS | 1315378-69-8 |
| MW: | 1268.47 D |
261.00€
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pep2-EVKI
Item number: TGM-TP1943-2mg
Description: pep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression...
| CAS | 1315378-67-6 |
| MW: | 1326.51 D |
225.00€
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pep2-SVKI
Item number: TGM-TP1944-2mg
Description: Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1)....
| CAS | 328944-75-8 |
| MW: | 1284.47 D |
156.00€
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QWF
Item number: TGM-TP1946-5mg
Description: Tripeptide substance P (SP) antagonist (IC50 = 90 µM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo. References: Hagiwara et al...
| CAS | 126088-82-2 |
| MW: | 697.78 D |
723.00€
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P110
Item number: TGM-TP1947-100mg
Description: Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell...
| MW: | 2411.8 D |
From 34.00€
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PKC zeta pseudosubstrate
Item number: TGM-TP1956-1mg
Description: Inhibitor of protein kinase C (PKC) zeta, attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC zeta pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by...
| MW: | 4673.59 D |
331.00€
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PM 102
Item number: TGM-TP1959-1mg
Description: Peptide that reverses the anticoagulant effect of heparin. Potently binds heparin (Kd = 36 nM in vitro). References: Cushing et al (2010) Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel he. antagonist. Eur.J.Pharmacol. 635 165 PMID:
| CAS | 1234564-95-4 |
| MW: | 5830 D |
298.00€
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PR 39 (porcine) acetate
Item number: TGM-TP1961L-10mg
Description: PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine) acetate reversibly binds to the alpha7 subunit of the proteasome and blocks degradation of NF-kappaB inhibitor IkappaBalpha by the ubiquitin-proteasome pathway. Target: Proteasome,...
From 186.00€
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Pam2CSK4
Item number: TGM-TP1962-1mg
Description: Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-alpha production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells. References: Boeglin et al (2011) Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell...
| CAS | 868247-72-7 |
| MW: | 1271.83 D |
815.00€
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