Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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BChE-IN-2
Item number: TGM-T61408-100mg
Description: BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, with a Ki value of 0.099 µM, and represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1]. Target: Others
| MW: | 365.52 D |
From 1,440.00€
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CXCR4 antagonist 3
Item number: TGM-T61409-100mg
Description: CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. With its potential for research on the human immunodeficiency...
| MW: | 365.52 D |
From 1,440.00€
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FLT3/ITD-IN-1
Item number: TGM-T61415-100mg
Description: FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD) with IC50 values of 38.2 nM for FLT3 and 144.1 nM for FLT3-ITD, and shows exceptional antiproliferative activities against several acute myeloid leukemia cell lines [1]. Target: Others
| MW: | 366.42 D |
From 1,440.00€
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Transthyretin-IN-1
Item number: TGM-T61423-100mg
Description: Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer's disease [1]. Target: Others
| MW: | 366.99 D |
From 1,440.00€
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NOS-IN-2
Item number: TGM-T61426-100mg
Description: NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 µM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for research on inflammatory disorders [1]. Target: Others
| MW: | 367.37 D |
From 1,440.00€
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HDAC-IN-33
Item number: TGM-T61429-100mg
Description: HDAC-IN-33 is a highly potent HDAC inhibitor, effectively inhibiting HDAC1, HDAC2, and HDAC6 with IC50 values of 24, 46, and 47 nM, respectively. This compound demonstrates significant antiproliferation activity against tumor cells and exhibits remarkable in vivo antitumor efficacy. Additionally,...
| MW: | 367.44 D |
From 1,440.00€
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Topoisomerase IIalpha-IN-4
Item number: TGM-T61431-100mg
Description: Topoisomerase IIalpha-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, selectively inhibiting TopoIIalpha with an IC50 value of 3.8 µM and TopoIIbeta with an IC50 value of 10.1 µM. It induces apoptosis and arrests the cell cycle in HepG2 cells, demonstrating...
| MW: | 367.44 D |
From 1,440.00€
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HDAC1-IN-5
Item number: TGM-T61433-100mg
Description: HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and alpha-tubulin, leading to the activation of caspase 3 and induction of apoptosis....
| MW: | 367.46 D |
From 1,440.00€
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HIF-1/2alpha-IN-1
Item number: TGM-T61442-100mg
Description: HIF-1/2alpha-IN-1, an orally active compound, functions as an inhibitor of HIF-2alpha. Its inhibitory effect on HIF-2alpha activity is significant, with an IC 50 value of 0.92 µM. Furthermore, HIF-1/2alpha-IN-1 has the ability to decrease HIF-1alpha levels. This compound is particularly valuable for...
| MW: | 368.35 D |
From 1,440.00€
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Trk-IN-7
Item number: TGM-T61443-100mg
Description: Trk-IN-7 (compound I-6) is a highly potent TRK inhibitor, with IC50 values of 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. It also shows significant inhibition of EML4-ALK (IC50 <15 nM) and ALK mutations G1202R, C1156Y, R1275Q, F1174L, L1197M, and G1269A (IC50 = 5-50 nM) [1]. Target: Others
| MW: | 368.36 D |
From 1,440.00€
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Nonsteroidal aromatase inhibitor 1
Item number: TGM-T61444-100mg
Description: Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. This potent inhibitory activity suggests its potential for breast cancer research [1]. Target: Others
| MW: | 368.39 D |
From 1,440.00€
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CXCR2 antagonist 4
Item number: TGM-T61447-100mg
Description: CXCR2 antagonist 4 (compound 7) is a highly potent inhibitor of CXCR2 with an IC50 of 0.13 µM and effectively inhibits the CXCL8-induced cytosolic calcium increase with an IC50 of 27 µM, demonstrating promising potential for anticancer research [1]. Target: Others
| MW: | 368.42 D |
From 1,440.00€
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