Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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FD2157
Item number: TGM-T79669-50mg
Description: FD2157, a photosensitive PI3K inhibitor, exhibits inhibitory IC50 values of 43 nM for PI3Kalpha, 83 nM for PI3Kbeta, 84 nM for PI3Kgamma, and 14 nM for PI3Kdelta. Upon exposure to 365 nm UV light, FD2157 effectively inhibits cancer cell proliferation and induces apoptosis [1]. Target: Apoptosis
| MW: | 625.01 D |
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Anti-inflammatory agent 56
Item number: TGM-T79670-100mg
Description: Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 µM, exhibits antioxidant and anti-inflammatory properties by inhibiting oxidative stress-induced cell death and neuroinflammation through the suppression of Keap1, COX-2, and iNOS. It demonstrates low acute...
| CAS | 2413127-32-7 |
| MW: | 476.43 D |
From 1,440.00€
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NF-kappaB-IN-11
Item number: TGM-T79671-100mg
Description: NF-kappaB-IN-11 (Compound 3i) is an inhibitor of NF-kappaB, effectively blocking TNF-alpha-induced NF-kappaB pathway activation and nuclear translocation of NF-kappaB, alongside reducing expression levels of phospho-IKK, IkappaBalpha, and NF-kappaB p65. Demonstrating anti-inflammatory properties, it...
| CAS | 2768833-35-6 |
| MW: | 326.34 D |
From 1,440.00€
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DUB-IN-7
Item number: TGM-T79672-50mg
Description: DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1]. Target: Others
| CAS | 2894064-79-8 |
| MW: | 309.37 D |
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LUNA18
Item number: TGM-T79673-50mg
Description: LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation. It is utilized in cancer research [1]. Target: Ras
| CAS | 2676177-63-0 |
| MW: | 1437.68 D |
From 3,111.00€
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HDAC-IN-64
Item number: TGM-T79674-50mg
Description: HDAC-IN-64 (Compound 13), an HDAC inhibitor, demonstrates potent inhibition of HDAC4/5/6/7/9 with IC50 values of 24, 45, 85, 31, and 37 nM, respectively. It exhibits anti-proliferative and anti-migration effects on prostate cancer (PCA) cells, specifically inhibiting the growth of LNCaP and RWPE-1 cells...
| MW: | 413.72 D |
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Antibacterial agent 153
Item number: TGM-T79675-50mg
Description: Antibacterial agent 153, a broad-spectrum agent, eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections [1]. Target: Others
| MW: | 682.88 D |
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SARS-CoV-2 3CLpro-IN-21
Item number: TGM-T79676-50mg
Description: SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 µM. It also exhibits inhibitory activity against SARS-CoV-1 3CL pro with an IC50 of 0.12 µM [1]. Target: Virus Protease
| MW: | 364.22 D |
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SARS-CoV-2-IN-58
Item number: TGM-T79677-50mg
Description: SARS-CoV-2-IN-58 (Compound 21H) is an antiviral agent targeting SARS-CoV-2, demonstrating an EC50 of 18 µM and specifically inhibiting the SARS-CoV-2 main protease (Mpro) with an IC50 of 0.35 µM [1]. Target: Virus Protease
| MW: | 463.89 D |
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PSEN1-IN-1
Item number: TGM-T79679-50mg
Description: PSEN1-IN-1 (Compound (+)-13b) is an inhibitor of PSEN1, exhibiting strong inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with IC50 values of 19 nM and 5.5 nM, respectively. It is employed in Alzheimer's disease research [1]. Target: Others
| MW: | 445.88 D |
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PSEN1-IN-2
Item number: TGM-T79680-50mg
Description: PSEN1-IN-2 (Compound 13K) is a potent inhibitor of PSEN1-APH1A and PSEN1-APH1B complexes, with IC50 values of 6.9 nM and 2.4 nM, respectively. This PSEN1 inhibitor is used in Alzheimer's disease research [1]. Target: Others
| MW: | 420.88 D |
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CA inhibitor 2
Item number: TGM-T79681-50mg
Description: Compound 4H is a potent carbonic anhydrase inhibitor with an IC50 value of 0.033 µM [1]. Target: Carbonic Anhydrase
| MW: | 335.39 D |
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