Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Anticancer agent 153
Item number: TGM-T79646-50mg
Description: Anticancer Agent 153 (Compound 3) promotes apoptosis through the generation of Reactive Oxygen Species (ROS) and elevates the loss of Mitochondrial Membrane Potential (MMP), effectively inhibiting cancer cell proliferation [1]. Target: Apoptosis
| MW: | 364.18 D |
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VEGFR/PARP-IN-1
Item number: TGM-T79647-50mg
Description: VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. This compound demonstrates considerable antiproliferative activity against BRCA...
| MW: | 517.58 D |
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CDK2-IN-19
Item number: TGM-T79648-50mg
Description: CDK2-IN-19 (Compound 32) is a selective, orally active CDK2 inhibitor (K i: 0.18 nM) that demonstrates anticancer activity in mice with OVCAR3 tumors [1]. Target: CDK
| MW: | 460.48 D |
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CB1R/AMPK modulator 1
Item number: TGM-T79649-50mg
Description: Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound activates AMPK and has been shown to decrease food intake and body weight, in addition to enhancing glucose tolerance and insulin sensitivity [1]. Target: Cannabinoid Receptor
| MW: | 557.45 D |
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HBV-IN-40
Item number: TGM-T79650-50mg
Description: HBV-IN-40 (Compound 11826096), with an IC50 of 0.7 µM, serves as a potent HBV inhibitor and exhibits antiviral activity [1]. Target: HBV
| MW: | 699.63 D |
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EGFR-IN-83
Item number: TGM-T79651-50mg
Description: EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50 values of 2.50 µM and 1.96 µM. Furthermore, EGFR-IN-83 is capable of inducing cell apoptosis [1]. Target: EGFR
| MW: | 410.39 D |
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Urease-IN-7
Item number: TGM-T79652-100mg
Description: Urease-IN-7 (Compound 5k) is a competitive inhibitor of the enzyme urease, with an IC50 of 3.33 µM and a K_i of 3.62 µM, offering potential applications in the study of peptic and gastric ulcers [1]. Target: Others
| CAS | 1129406-54-7 |
| MW: | 389.24 D |
From 1,440.00€
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CRM1-IN-1
Item number: TGM-T79654-50mg
Description: CRM1-IN-1 (Compound KL1), a noncovalent inhibitor of CRM1, promotes nuclear degradation of CRM1 with an IC50 of 0.27 µM, inhibits CRM1-mediated nuclear export, suppresses cell proliferation, and induces apoptosis in colorectal cancer cells [1]. Target: CRM1
| MW: | 504.7 D |
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CRM1-IN-2
Item number: TGM-T79655-50mg
Description: CRM1-IN-2 (Compound KL2) is a noncovalent inhibitor of CRM1, localizing it to the nuclear periphery, reducing its nuclear presence, and inhibiting its nuclear export function. It effectively inhibits the growth of colorectal cancer cells and induces apoptosis [1]. Target: CRM1
| MW: | 504.7 D |
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MeOIstPyrd
Item number: TGM-T79657-100mg
Description: MeOIstPyrd is an anti-skin cancer agent that inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. It induces DNA damage, activates p53, increases its half-life, and stabilizes p53 via ser15 phosphorylation. Additionally, MeOIstPyrd...
| CAS | 2308548-54-9 |
| MW: | 304.37 D |
From 1,440.00€
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PI3Kdelta-IN-14
Item number: TGM-T79658-50mg
Description: PI3Kdelta-IN-14 (Compound (S)-29), a selective PI3Kdelta inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of PI3Kdelta, exhibiting anti-inflammatory properties by impeding the PI3K/AKT pathway and alleviating acute lung injury (ALI) [1]. Target:...
| MW: | 514.94 D |
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SARS-CoV-2 3CLpro-IN-17
Item number: TGM-T79660-50mg
Description: Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 µM [1]. Target: SARS-CoV
| MW: | 323.39 D |
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