Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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EGFR-IN-86
Item number: TGM-T78862-50mg
Description: EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell cycle arrest in U87 cells [1]. Target: EGFR
| MW: | 423.49 D |
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HSP90-IN-25
Item number: TGM-T78863-50mg
Description: HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically impedes its ATPase function [1]. Target: HSP
| MW: | 556.69 D |
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LYP-IN-3
Item number: TGM-T79634-50mg
Description: LYP-IN-3 (compound D34) is a selective Lymphoid-tyrosine phosphatase (LYP) inhibitor (Ki=0.93 µM) that modulates the T-cell receptor (TCR) signaling pathway during tumor progression. It promotes T-cell activation, hinders M2 macrophage polarization, and increases PD-1/PD-L1 expression. When combined...
| MW: | 589.66 D |
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LYP-IN-4
Item number: TGM-T79635-50mg
Description: LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 µM, IC50=3.52µM), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and...
| MW: | 593 D |
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PKM2-IN-4
Item number: TGM-T79636-50mg
Description: Compound 5C, referred to as Pkm2-in-4, is a selective PKM2 inhibitor (IC50 = 0.35 µM) that modulates pyruvate-dependent respiration and promotes mitochondrial H2O2 production rate and electron transport system coupling [1]. Target: Others
| MW: | 453.62 D |
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Lepadin E
Item number: TGM-T79638-100mg
Description: Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound...
| CAS | 444914-19-6 |
| MW: | 421.66 D |
From 1,867.00€
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Lepadin H
Item number: TGM-T79639-100mg
Description: Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing lipid peroxidation. It simultaneously decreases SLC7A11 and GPX4 levels while upregulating ACSL4 expression, thereby inducing ferroptosis via the...
| CAS | 412328-25-7 |
| MW: | 419.64 D |
From 1,867.00€
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ZNL-05-044
Item number: TGM-T79640-50mg
Description: ZNL-05-044, a CDK11 inhibitor, exhibits IC50 values of 0.23 µM for CDK11A and 0.27 µM for CDK11B, as determined by NanoBRET assay. It induces G2/M cell cycle arrest and disrupts RNA splicing [1]. Target: CDK
| MW: | 477.41 D |
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IV-275
Item number: TGM-T79642-50mg
Description: IV-275 is a dual inhibitor targeting the bromodomains of both BRG1 and BRM. This compound not only augments DNA damage when combined with Temozolomide and Bleomycin but also suppresses the invasiveness of GBM cells. Furthermore, IV-275 amplifies Temozolomide-induced cell death and its apoptosis-inducing...
| MW: | 360.35 D |
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PD-1/PD-L1-IN-33
Item number: TGM-T79643-100mg
Description: PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor with an IC50 of 6.3 nM, effectively impedes the interaction between PD-1 and PD-L1. It enhances T-cell proliferation, activation, and infiltration within tumor environments, thereby exhibiting immunomodulatory and anticancer properties [1]. Target:...
| CAS | 2975602-78-7 |
| MW: | 425.53 D |
From 1,583.00€
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Antidiabetic agent 2
Item number: TGM-T79644-50mg
Description: Compound 56 (Antidiabetic agent 2) is a glucose-uptake promoter that inhibits DPP-4, PTP-1B, alpha-amylase, and alpha-glucosidase, with IC50 values of 0.036, 0.042, 0.241, and 0.185 µM, respectively. This agent effectively decreases blood glucose levels [1]. Target: Glucosidase
| MW: | 599.59 D |
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Tubulin polymerization-IN-48
Item number: TGM-T79645-50mg
Description: Tubulin polymerization-IN-48 (Compound 4k) is a tubulin polymerization inhibitor that moderately disrupts the microtubule network and impedes the proliferation of neuroblastoma cancer cells, with IC50 values of 79 nM and 165 nM for the Chp-134 and Kelly cell lines, respectively [1]. Target: Others
| MW: | 384.26 D |
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