Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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FRF-06-057
Item number: TGM-T203400-10mg
Description: FRF-06-057 is an allosteric ATP EGFR inhibitor targeting both wild-type and mutant EGFR, with IC50 values of 17 nM (LR/TM), 29 nM (LR/TM/CS), 220 nM (LR), and >1000 nM (WT). Target: EGFR
| MW: | 363.39 D |
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DOX-PEG-Cy3
Item number: TGM-T203419-10mg
Description: DOX-PEG-Cy3 (Doxorubicin-PEG-Cy3) is a Cy3-labeled DOX-PEG conjugate. The Cy3 fluorophore is commonly used for applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. DOX is a...
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Ifebemtinib hydrochloride
Item number: TGM-T203420-10mg
Description: Ifebemtinib (BI-853520) hydrochloride is a potent FAK (focal adhesion kinase) inhibitor with oral bioavailability, exhibiting an IC50 of 1 nM for recombinant FAK. Ifebemtinib hydrochloride demonstrates antiproliferative activity against cancer cells. Target: FAK
| Keywords: | IN-10018 hydrochloride , BI-853520 hydrochloride |
| MW: | 625.01 D |
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DDHF20
Item number: TGM-T203435-10mg
Description: DDHF20 is an inhibitor of Staphylococcus aureus, specifically targeting and inhibiting its thioredoxin reductase (TrxR) by acting as a competitive inhibitor at the NADPH binding site. DDHF20 shows potential for research in combating infections related to Staphylococcus aureus. Target: Reductase
| MW: | 500.58 D |
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Moxifloxacin-d
Item number: TGM-T203444-10mg
Description: Moxifloxacin-d4 hydrochloride (BAY 12-8039-d4) is the hydrochloride salt form of deuterium-labeled Moxifloxacin (Moxifloxacin). This compound acts as an orally effective antibacterial agent and is utilized in research concerning acute bacterial sinusitis, acute bacterial exacerbations of chronic...
| MW: | 441.92 D |
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PDE1-IN-8
Item number: TGM-T203453-10mg
Description: PDE1-IN-8 (Compound 3f) acts as an inhibitor of PDE1, with an IC50 of 11 nM. It hinders cAMP and cGMP signaling pathways, impeding the differentiation and proliferation of cells into myofibroblasts, and demonstrates antifibrotic effects in the Bleomycin-induced rat model of pulmonary fibrosis. Target:...
| MW: | 408.32 D |
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VEGFR-2/AKT-IN-2
Item number: TGM-T203454-10mg
Description: VEGFR-2/AKT-IN-2 (Compound 5) is an inhibitor of VEGFR-2/AKT, with an IC50 of 0.061 µM for VEGFR in human liver cancer cells. It reduces total and phosphorylated AKT in cells, increases BAX and caspase-3 levels, and decreases Bcl-2, thereby inducing apoptosis. Additionally, VEGFR-2/AKT-IN-2 halts the...
| MW: | 437.49 D |
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SARS-CoV-2 3CLpro-IN-29
Item number: TGM-T203457-10mg
Description: 3CLPro-IN-3 (Compound A36) is an inhibitor of SARS-CoV-2 3CLpro with an IC50 value of 51.3 nM. It exhibits antiviral activity against human coronaviruses 229E, OC43, and the murine coronavirus MHV.
| MW: | 558.94 D |
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Dextran-CY5
Item number: TGM-T203494-10mg
Description: Dextran-CY5 is dextran labeled with the fluorescent dye CY5, which has a peak excitation wavelength of 633 nm and a peak emission wavelength of 670 nm. Dextran-CY5 is useful for visualizing the specific subcellular distribution of glucans at the nanoscale level. Target: Others
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alpha-Glucosidase-IN-77
Item number: TGM-T203496-10mg
Description: alpha-Glucosidase-IN-77 (Compound H7) is a non-competitive alpha-glucosidase inhibitor with an IC50 of 1.25 µM. It reduces blood glucose levels, improves glucose tolerance, regulates gut microbiota, and exhibits hepatoprotective effects in a mouse model of type 2 diabetes. Target: glycosidase
| MW: | 499.46 D |
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WRN inhibitor 15
Item number: TGM-T203503-10mg
Description: WRN inhibitor 15 (Compound 9) is a WRN inhibitor with antitumor properties, displaying IC50 values of 37.9, 40.2, and 46.6 µM in PC3, LNCaP, and HeLa cells, respectively, making it suitable for prostate cancer research. Target: DNA/RNA Synthesis
| MW: | 301.29 D |
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MCG-02
Item number: TGM-T203518-10mg
Description: MCG-02 is an inhibitor of cruzain (CRZ) and cathepsin L-like protease (CATL), capable of inhibiting CRZ in Trypanosoma cruzi and CATL in Trypanosoma brucei, with IC50 values of 0.2 µM and 0.02 µM, respectively. Target: Parasite
| MW: | 275.33 D |
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