Enteropeptidase is a membrane-bound serine protease that converts the inactive enzyme trypsinogen to the active form trypsin, a protease that catalyzes the digestion of proteins in the gut. It is composed of an N-terminal domain with a transmembrane segment that anchors enteropeptidase to the cell membrane and an...

EK initiates activation of pancreatic proteases by converting trypsinogen to trypsin, which in turn activates chymotrypsin, carboxypeptidases and elastases. Located in the intestinal brush border, it is a disulfide bond-linked dimer of the heavy and light chains, which are derived from the same single-chain...