P21-activated kinase-1 (PAK1) is an enzyme associated with multiple metabolic networks and different types of cancers.PAK1 (RAC/CDC42-activated kinase 1) is the major oncogenic/ageing kinase, and its dysfunction extends the healthy lifespan of C. elegans by activating HSP16 gene. The p21 protein...

Anti-PAK 1/2/3 pT402 antibody is directed against rat PAK protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification and is specific for the phosphorylated protein. The immunolabeling of PAK is completely eliminated by ?-phosphatase treatment. Reactivity is expected from...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Protein function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly...