Anti-mGluR1a antibodies are affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody. This antibody is directed against rat mGluR1a. Reactivity is expected from mouse. Cross reactivity from other...

The metabotropic glutamate receptors have been organised into three groups. mGluR5 and mGluR1 make up group I which, when activated, stimulates phospholipase C and activates protein kinase C to hydrolyse phosphoinositide phospholipids in the cell membrane. Group I mGluRs, but not other groups, are activated by 3,...

Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May...