Protein function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [The UniProt Consortium]

Detyrosinated alpha-tubulin is a form of the cytoskeletal protein alpha-tubulin that has been post-translationally modified by the tubulin carboxypeptidases vasohibin 1 (VASH-1) and VASH-2, which remove the C-terminal tyrosine from alpha-tubulin. Detyrosination of alpha-tubulin occurs in the cytosol and exposes two...

Delta2 alpha-Tubulin is a non-tyrosinatable variant of tubulin that lacks a carboxy-terminal glutamyl-tyrosine group on its alpha-subunit. It is expressed in a wide variety of cell types, including fibroblasts and adrenal cortical cells, and accounts for approximately 35% of brain tubulin. Delta2 alpha-Tubulin is...