Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The SCAP antibody targets SREBP cleavage-activating protein, a key membrane-bound regulator of cholesterol and lipid homeostasis encoded by the SCAP gene. This protein acts as a sterol sensor that governs the trafficking and activation of...

In 1X PBS, pH 7.4, with 0.09% sodium azide. SCAP is a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically...