27 products were found matching "K26171"!

0.5mg/ml if reconstituted with 0.2ml sterile DI water. SR2/MAC30/TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels. Protein function: Intracellular sigma-2 receptor that binds histatin 1/HN1 (Hst 1) at the endoplasmic reticulun (ER) membrane, which is...

WLB-89462 is a ligand of sigma intracellular receptor 2 (sigma2 receptor). It selectively binds to the sigma2 receptor (Ki = 13 nM) over the sigma1 receptor (Ki = 1,777 nM). WLB-89462 (10 µM) prevents decreases in the number of dopaminergic neurons in an in vitro model of neurodegeneration using primary rat neurons...

A dual sigma receptor antagonist (Kis = 0.0141 and 0.00231 µM for the sigma1 and sigma2 receptors, respectively) and DAT inhibitor (Ki = 0.311 µM), selective for the sigma1 and sigma2 receptors and DAT over SERT (Ki = 2.83 µM) but also binds to NET (Ki = 0.232 µM), inhibits dopamine uptake in rat striatal...

Protein Function: Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at...

Protein Function: Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at...

Protein Function: Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the...

Protein Function: Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the...

Protein Function: Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the...

Protein Function: Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the...

Protein Function: Sigma-2 receptor which contributes to ameliorate dysfunctional cellular processes and slow degenerative progression by regulating cell functions including cholesterol biosynthesis/trafficking, membrane trafficking, autophagy, lipid membrane-bound protein trafficking, and receptor stabilization at...

Protein Function: Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the...

Protein Function: Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking, and stabilization of receptors at the cell surface, thereby contributing to the...