24 products were found matching "K25015"!

Description: Pomotrelvir (PBI-0451) is a selective, orally administered inhibitor of the SARS-CoV-2 3CL protease with antiviral properties, making it suitable for novel coronavirus (COVID-19) research. Target: Others. Smiles: ClC1=C2C(C=C(C(N[C@@H](CC3CC3)C(N[C@@H](C[C@H]4C(=O)NCCC4)C#N)=O)=O)N2)=CC=C1

Description: ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 µM), with moderate MW and good enzyme and antiviral inhibitory activity. Target: SARS-CoV, Virus Protease. Smiles: CC(C)(C)NC(=O)[C@H](N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1. References: Jacobs J , Grum-Tokars V , Zhou Y , et al....

Description: (Rac)-X77 (MUN91789) is a potent SARS- CoV- 2 main protease inhibitor. Target: SARS-CoV. Smiles: CC(C)(C)c1ccc(cc1)N(C(C(=O)NC1CCCCC1)c1cccnc1)C(=O)c1cnc[nH]1. References: Andrianov A M , Kornoushenko Y V , Karpenko A D , et al. Computational Discovery of Small Drug-like Compounds as Potential...

Description: PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) . Target: SARS-CoV. Smiles: C(N[C@@H](C[C@H]1C(=O)NCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@](C)(C)C)=O)[H])[H]. References: Li J, et al. Nirmatrelvir exerts distinct antiviral potency...

Description: PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively. PF-00835231 is the active compound of the first anti-3CLpro regimen in clinical trials. Target: SARS-CoV. Smiles:...

Description: Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM. Target: SARS-CoV. Smiles: Cn1nc(cc(c(/N=C(\NC(N2Cc3nn(C)cn3)=O)/N(Cc(cc(c(F)c3)F)c3F)C2=O)c2)Cl)c2c1. References: Yuto Unoh, et al. Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease...

Description: Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus. Target: 5-HT Receptor, Influenza Virus. Smiles: Cl.CN(C)CCCSc1ccccc1NC(=O)C=Cc1ccccc1. References: Chen L, et al....

Description: Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2...

rac-X77 is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro, IC50 = 4.1 µM).Formal Name: N-cyclohexyl-alpha-[[4-(1,1-dimethylethyl)phenyl](1H-imidazol-5-ylcarbonyl)amino]-3-pyridineacetamide. CAS Number: 2144491-78-9. Molecular...

PF-07321332 is an orally bioavailable inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), with a Ki value of 3.11 nM. It also inhibits Mpro from other members of the Betacoronavirus genus, including SARS-CoV-1, HKU1-CoV, OC43-CoV,...

Ensitrelvir is an orally bioavailable inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), with an IC50 value of 0.013 µM. It is selective for Mpro over HIV-1 protease and the human proteases caspase-2, chymotrypsin, thrombin, and...

PF-00835231 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro, Kis = 4 and 0.27 nM, respectively). It reduces the infectivity of SARS-CoV and common cold human coronavirus 229E (HCoV-229E) in Vero cells (EC50s = 4.8...