Description: Punicalin exerts anti-inflammatory, antioxidative, and anti-hepatotoxic activities, it shows inhibitory activity on HIV-1 reverse transcriptase in a dose-dependent manner, with an IC50 of 0.11 microg/ml (0.14 microM). Target: HIV Protease, HBV. Smiles:...

Punicalin is an ellagitannin that has been found in P. granatum and has diverse biological activities. It inhibits the interaction between the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), also known as the surface glycoprotein RBD, and angiotensin-converting...

Withanone is a phytochemical that has been found in W. somnifera and has diverse biological activities. It inhibits the protein-protein interaction between human angiotensin-converting enzyme 2 (ACE2) and the SARS-CoV-2 spike protein receptor-binding domain (IC50 = 0.33 ng/ml). Withanone (10 µg/ml) protects against...

Description: Tixagevimab (AZD8895) is a human monoclonal antibody that targets the receptor binding domain (RBD) of SARS-CoV-2, neutralizing the virus by preventing the S-glycoprotein from binding to its receptor through attachment to the RBD and the S-glycoprotein ectodomain [1].

Description: Cilgavimab (AZD-1061, COV2-2130), a humanized SARS-CoV-2-neutralizing monoclonal antibody, is part of the monoclonal antibody combination AZD7442 with Tixagevimab and demonstrates protective effects in mouse models of SARS-CoV-2 infection [1].