28 products were found matching "K22745"!

viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1, IC50s = 34 and 83 nM for the human and mouse enzymes, respectively). It induces ferroptosis in glutathione peroxidase 4 (Gpx4) knockout Pfa1 mouse embryonic fibroblasts expressing human or mouse FSP1, an effect that can be reversed...

icFSP1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1). It induces condensation and phase separation of FSP1 in cells when used at a concentration of 2.5 µM but does not inhibit FSP1 enzymatic activity in a cell-free assay (IC50 = > 30 µM). icFSP1 induces ferroptosis in HT-1080 fibrosarcoma cells in a...

iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1). It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis...

Cayman's FSP1 Fluorescent Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human FSP1, a negative regulator of the ferroptosis pathway. The assay measures the reduction of resazurin by FSP1 into resorufin, which can be easily quantified using a fluorescence...

Ferroptosis suppressor protein 1 (FSP1), also known as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), is a flavoprotein and NAD(P)H-dependent oxidoreductase that inhibits ferroptosis in a glutathione peroxidase 4- and glutathione-independent manner. It is encoded by AIFM2 in humans and is composed of a...

FSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1, IC50 = 313 nM). It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1, IC50 = >100 µM). FSEN1 induces cell death in GPX4-/- H460 non-small cell lung cancer (NSCLC) cells (EC50 = 69.36 nM) but not control H460 cells expressing...

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. Protein function: Oxidoreductase, which...

Ferroptosis suppressor protein 1 (FSP1), also known as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), is a flavoprotein and NAD(P)H-dependent oxidoreductase that inhibits ferroptosis in a glutathione peroxidase 4 (GPX4) and glutathione-independent manner. It is encoded by AIFM2 in humans and is...

Protein function: A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical- trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with...

Protein function: A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical- trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with...

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. Protein function: A NAD(P)H-dependent...