13 products were found matching "K21037"!
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Pradefovir (mesylate)
Item number: Cay45047-1
A liver-activated prodrug form of adefovir, it is converted to adefovir diphosphate in the liver in rats at 30 mg/kg. SMILES: O=[P@]1(O[C@H](C2=CC(Cl)=CC=C2)CCO1)COCCN3C4=NC=NC(N)=C4N=C3.CS(O)(=O)=O. InChi Code:...
| Keywords: | MB06866, 9-[2-[[(2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl]methoxy]ethyl]-9H-purin-6-amine,... |
| Application: | Liver-activated Adefovir prodrug, reverse transcriptase inhibitor |
| CAS | 625095-61-6 |
| MW: | 519.89 D |
From 119.00€
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Adefovir dipivoxil
Item number: TGM-T1675-25mg
Description: Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). Target: HBV, Reverse Transcriptase, Others. Smiles:...
| Keywords: | Preveon, GS 0840, Hepsera |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 142340-99-6 |
| MW: | 501.47 D |
From 30.00€
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Entecavir-d2
Item number: Cay37212-1
Entecavir-d2 is intended for use as an internal standard for the quantification of entecavir (Cay-36926, Cay-13831) by GC- or LC-MS. Entecavir is an antiviral nucleoside analog of 2'-deoxyguanosine (Cay-9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM). It undergoes...
| Keywords: | 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
| Application: | GC-MS, LC-MS internal standard, quantification, HBV reverse transcriptase inhibitor, nucleoside analog |
| MW: | 279.3 D |
1,097.00€
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Protein P (P), partial, Heron hepatitis B virus, recombinant
Item number: CSB-EP319601HGG.1
Organism: Heron hepatitis B virus (HHBV). Source: E.coli. Expression Region: 376-565aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: SYLRGNTSWP NRVTGRIFLV DKNSRNTEEA RLVVDFSQFS KGKNAMRFPK YWCPNLTTLR RILPVGMPRI SLDLSQAFYH LPLAPASSSR LAVSDGKQVY...
| Keywords: | P, Protein P, EC=2.7.7.7, EC=2.7.7.49, EC=3.1.26.4, Ribonuclease H, RNA-directed DNA polymerase, DNA-directed DNA... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | Heron hepatitis B virus (HHBV) |
| MW: | 28.7 kD |
From 364.00€
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Tenofovir
Item number: TGM-T1649-100mg
Description: Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used...
| Keywords: | TDF, GS 1278, PMPA |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 147127-20-6 |
| MW: | 287.21 D |
From 36.00€
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Telbivudine
Item number: TGM-T1513-100mg
Description: Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of telbivudine is Nucleoside Analog. Target: Others, Reverse Transcriptase, HBV. Smiles:...
| Keywords: | L-Thymidine, Epavudine, NV 02B |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 3424-98-4 |
| MW: | 242.23 D |
From 39.00€
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Torcitabine
Item number: TGM-T34904-1mL
Description: Torcitabine is useful against the hepatitis B virus. Target: Others. Smiles: Nc1ccn([C@H]2C[C@@H](O)[C@H](CO)O2)c(=O)n1. References: Qi X, Xiong S, Yang H, Miller M, Delaney WE 4th. In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents. Antivir...
| Keywords: | NV-02C, L-dC, NV 02C, L-Deoxycytidine |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 40093-94-5 |
| MW: | 227.22 D |
From 47.00€
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Valtorcitabine dihydrochloride
Item number: TGM-T29095-100mg
Description: Valtorcitabine dihydrochloride, a DNA polymerase inhibitor, is used potentially for the treatment of HBV infection. Target: Others. Smiles: CC([C@@H](C(O[C@@H]1C[C@@H](n(ccc(N)n2)c2=O)O[C@H]1CO)=O)N)C.Cl.Cl. References: Keeffe EB, Marcellin P. New and emerging treatment of chronic hepatitis B. Clin...
| Keywords: | NM-147, LDC300, LDC 300, NM 147 monoVal-L-dC, NM147, LDC-300 |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 359689-54-6 |
| MW: | 399.27 D |
From 1,725.00€
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Tenofovir alafenamide hemifumarate
Item number: TGM-T7282-100mg
Description: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Target: Reverse Transcriptase, HIV Protease. Smiles:...
| Keywords: | GS-7340 (hemifumarate), Tenofovir alafenamide fumarate |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 1392275-56-7 |
| MW: | 534.51 D |
From 38.00€
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Adefovir
Item number: TGM-T7447-100mg
Description: Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. Target: Telomerase, Reverse Transcriptase, HBV. Smiles: CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(C)(C)C. References: Delmas J...
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 106941-25-7 |
| MW: | 273.19 D |
From 39.00€
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Pradefovir mesylate
Item number: TGM-T19526-10mg
Description: Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 µM. Target: P450. Smiles: CS(O)(=O)=O.Nc1c2ncn(CCOC[P@@](OCC3)(O[C@@H]3c3cccc(Cl)c3)=O)c2ncn1. References: Lin CC, et al. Metabolic activation of Pradefovir by CYP3A4 and...
| Keywords: | Pradefovir mesilate, Hepavir B, Remofovir mesylate |
| Application: | Targets Hepadnaviridae DNA polymerase / reverse transcriptase / ribonuclease H (P) |
| CAS | 625095-61-6 |
| MW: | 519.9 D |
From 131.00€
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Entecavir
Item number: Cay36926-10
Entecavir is an antiviral nucleoside analog of 2'-deoxyguanosine (Cay-9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM). It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate. Entecavir reduces virion DNA in the culture supernatant of HepG2...
| Keywords: | BMS 200475, SQ 34,676, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one |
| Application: | HBV reverse transcriptase inhibitor, antiviral nucleoside analog |
| CAS | 142217-69-4 |
| MW: | 277.3 D |
From 69.00€
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