47 products were found matching "K18438"!

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides.

Solulibility: DMSO: Sparingly Soluble: 1-10 mg/mL: .

Human PDE10A1 (GenBank Accession No. NM_001130690), a.a. 2-789(end) with N-terminal GST-tag, MW=116 kDa, expressed in Sf9 cells via a Baculovirus expression system. One unit is defined as the amount of enzyme that will convert 1 pmole of 3',5'-cAMP to 5'- AMP per min at 37°C. Assay condition: 10 mM Tris-HCl, pH 7.4,...

The PDE10A Assay Kit is designed for identification of PDE10A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE10A to the binding agent. PDE10A is a dual substrate PDE highly expressed in striatal medium spiny neurons. PDE10A...

Active human PDE10A2 (GenBank Accession No. NM_006661), full length with N-terminal GST tag, MW= 116 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A, IC50 = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits 14276, Cay-ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063...

White powder. Soluble in DMSO, ethanol or dimethylformamide. Alkaloid antispasmodic drug that most usually treats visceral spasm or vasospasm. It has also been used in the treatment of erectile dysfunction. Smooth muscle relaxant and vasodilator. Phosphodiesterase PDE10A inhibitor. Show to have antiviral and...

Protein function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a...

Active mouse PDE10A GenBank Accession No. NM_011866), full length with N-terminal GST tag, MW=114.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Active rat PDE10A GenBank Accession No. NM_022236), amino acids 449-end with Nterminal GST tag, MW=66 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

The PDE10A1 Assay Kit is designed for identification of PDE10A1 inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE10A1 to the binding agent. The key to the PDE10A1 Assay Kit is the specific binding agent. Using this kit, only two...

Recombinant HEK293 cell line expressing human PDE10A (phosphodiesterase 10A , accession number NM_001130690). Format Each vial contains 1 X 10^6 cells in 1 ml of 10% DMSO. Introduction PDE10A plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. PDE10A hydrolyzes...