23 products were found matching "K17690"!

4beta-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation. It is formed from cholesterol by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. 4beta-hydroxy Cholesterol has an unusually long half-life in plasma (~60...

Dehydro nifedipine is an active metabolite of nifedipine (Cay-11106), a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Dehydro nifedipine inhibits glucose uptake...

Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors). It is selective for CYP3A over other CYP isomers (IC50 = >25 µM for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 µM) or affect HIV...

N-Desethyl vardenafil is a metabolite of vardenafil (Cay-14930), a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5.Formal Name: 2-[2-ethoxy-5-(1-piperazinylsulfonyl)phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one. CAS Number: 448184-46-1. Molecular...

4beta-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 4beta-hydroxy cholesterol (Cay-19518) by GC- or LC-MS. 4beta-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation. It is...

16alpha-hydroxy Prednisolone is a metabolite of 22(R)-budesonide. It is formed from 22(R)-budesonide by the cytochrome P450 (CYP) isoform CYP3A in human liver microsomesFormal Name: (11beta,16alpha)-11,16,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione. CAS Number: 13951-70-7. Molecular Formula: C21H28O6. Formula...

Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Cay-14152). It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM). Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine...

In 1X PBS, pH 7.4, with 0.09% sodium azide. CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 1-502aa. Protein Length: Full Length. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: MDLIPNLAVE TWLLLAVSLV LLYLYGTRTH GLFKRLGIPG PTPLPLLGNV LSYRQGLWKF DTECYKKYGK MWGTYEGQLP VLAITDPDVI RTVLVKECYS VFTNRRSLGP VGFMKSAISL AEDEEWKRIR...

Description: 4beta-hydroxy Cholesterol is a useful organic compound for research related to life sciences. The catalog number is T21530 and the CAS number is 17320-10-4. Target: Others. Smiles: CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4[C@@H](O)[C@@H](O)CC[C@]4(C)C3CC[C@]12C

Description: Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 µM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is...