- Search results for K17388
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49 products were found matching "K17388"!
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Item number: ELK-ELK5478.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Rock2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Rock2. Next,...
Keywords: | ROCK2, ROCK-II, KIAA0619, EC=2.7.11.1, p164 ROCK-2, Rho kinase 2, Rho-associated protein kinase 2, Rho-associated,... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: ELK-ELK7603.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Rock2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Rock2. Next,...
Keywords: | ROCK2, ROCK-II, KIAA0619, EC=2.7.11.1, p164 ROCK-2, Rho kinase 2, Rho-associated protein kinase 2, Rho-associated,... |
Application: | ELISA |
Species reactivity: | human |
From 303.00€
*
Item number: ELK-ELK0700.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Rock-2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Rock-2....
Keywords: | ROCK2, ROCK-II, KIAA0619, EC=2.7.11.1, p164 ROCK-2, Rho kinase 2, Rho-associated protein kinase 2, Rho-associated,... |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: LKT-Y1000.25
Y27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), Y27632 binds to the catalytic site of ROCK, preventing binding of Ras-related GTPase Rho A, which is involved in actin cytoskeleton reorganization, cell adhesion, and cell migration. Y27632 inhibits downstream endothelin and TGF- -related...
Application: | ROCK inhibitor |
CAS | 129830-38-2 |
MW: | 320.26 D |
From 121.00€
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Item number: Cay19920-5
Ripasudil is an inhibitor of Rho-associated kinase 1 (ROCK1) and ROCK2 (IC50s = 51 and 19 nM, respectively). It is selective for ROCK1 and ROCK2 over protein kinase A catalytic subunit alpha (PKACalpha) and PKC (IC50s = 2,100 and >10,000 nM, respectively). Ripasudil (0.4%) reduces intraocular pressure in cynomolgus...
Keywords: | K-115, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-isoquinoline, monohydrochloride, dihydrate |
Application: | ROCK1/ROCK2 inhibitor |
CAS | 887375-67-9 |
MW: | 395.9 D |
From 54.00€
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Item number: Cay38248-1
Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2, IC50 = 50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits the phosphorylation of myosin light-chain (MLC) in a cell-based assay (IC50 = 98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 273, 300 nm....
Keywords: | (S)-Chroman 1,... |
Application: | ROCK2 inhibitor |
CAS | 1273579-40-0 |
MW: | 436.5 D |
From 66.00€
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Item number: 600-401-998
Protein function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1,...
Keywords: | Anti-phospho-ROCK2, Anti-phospho-ROCK-II, Anti-phospho-KIAA0619, Anti-phospho-p164 ROCK-2, EC=2.7.11.1, Anti-phospho-Rho... |
Application: | ELISA, IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
684.00€
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Item number: Cay19180-1
Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK...
Keywords: | GSK269962A, GSK269962B,... |
Application: | Selective ROCK inhibitor |
CAS | 850664-21-0 |
MW: | 570.6 D |
From 50.00€
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Item number: Cay16278-5
RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2...
Keywords: | N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-urea |
Application: | ROCK inhibitor |
CAS | 1342278-01-6 |
MW: | 326.4 D |
From 82.00€
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Item number: Cay16708-5
SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK2 than ROCK1 in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively). At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50%...
Keywords: | N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide |
Application: | ROCK inhibitor |
CAS | 1072959-67-1 |
MW: | 408.5 D |
From 60.00€
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Item number: Cay34682-1
Chroman 1 is an inhibitor of Rho-associated kinase 2 (ROCK2, IC50 = 50s = 1,740 and 127 nM, respectively). Chroman 1 inhibits phosphorylation of myosin light chain (MLC) in a cell-based assay (IC50 = 98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Water: 5 mM. SMILES:...
Keywords: | (S)-Chroman 1, (S)-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-methoxychromane-3-carboxamide,... |
Application: | ROCK2 inhibitor |
MW: | 527.4 D |
From 77.00€
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Item number: Cay17055-10
KD 025 is an inhibitor of Rho-associated kinase 2 (ROCK2, IC50 = 0.105 µM). It is selective for ROCK2 over ROCK1 (IC50 = 24 µM). KD 025 (10 µM) decreases the expression of connective tissue growth factor (CTGF) and induces remodeling of the actin cytoskeleton in isolated human ileal fibrotic smooth muscle cells. It...
Keywords: | SLx-2119, 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide |
Application: | ROCK2 inhibitor |
CAS | 911417-87-3 |
MW: | 452.5 D |
From 75.00€
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