22 products were found matching "K14461"!
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Anti-Recombinant NPC1L1, clone C132964
Item number: E-AN303344L.100
Protein function: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity)....
| Keywords: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1, Anti-NPC1-like intracellular cholesterol transporter 1, Recombinant... |
| Application: | WB |
| Host: | Rabbit |
| Species reactivity: | human,mouse,rat |
From 171.00€
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NPC1L1 Protein, Human, Recombinant (His & HA)
Item number: TGM-TMPH-04041-100ug
Description: NPC1L1 Protein, Human, Recombinant (His & HA) is expressed in E. coli with N-6xHis, C-HA. The accession number is Q9UHC9.
| Keywords: | NPC1L1 , NPC1-like intracellular cholesterol transporter 1 , Niemann-Pick C1-like protein 1 |
| MW: | 33.1 kD |
From 122.00€
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Ezetimibe
Item number: Cay16331-25
Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1, Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes. It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day). Ezetimibe (346 nM) also reduces the...
| Keywords: | Ezetrol, SCH 58235, (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Application: | NPC1L1 inhibitor, intestinal cholesterol absorption inhibitor |
| CAS | 163222-33-1 |
| MW: | 409.4 D |
From 114.00€
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Ezetimibe-d4
Item number: Cay25044-1
Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe (Cay-16331) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of...
| Keywords: | Ezetrol-d4,... |
| Application: | Internal standard, GC-MS, LC-MS |
| CAS | 1093659-89-2 |
| MW: | 413.5 D |
734.00€
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Ezetimibe
Item number: TGM-T1593-200mg
Description: Ezetimibe (SCH 58235) is a dietary cholesterol absorption inhibitor that exerts its physiologic effect by decreasing cholesterol absorption. Target: NPC1L1, Autophagy, Nrf2, Others. Smiles: C(C[C@H](O)C1=CC=C(F)C=C1)[C@@H]2[C@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4. References: Clader JW, et al. J...
| Keywords: | SCH 58235 |
| Application: | Targets Niemann-Pick C1-like protein 1 (NPC1L1) |
| CAS | 163222-33-1 |
| MW: | 409.43 D |
From 39.00€
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Ezetimibe
Item number: BPS-27749-2
Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.
| Keywords: | ezetimibe, Zetia, (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one, |
| Application: | Cholesterol absorption inhibitor, NPC1L1 inhibitor |
| MW: | 409.4 D |
From 367.00€
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3'-(2-Fluorophenyl) Ezetimibe
Item number: Cay34855-1
3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor ezetimibe (Cay-16331).Formal Name: (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. CAS Number: 1798008-25-9. Molecular Formula: C24H21F2NO3. Formula Weight: 409.4. Purity:...
| Keywords: | (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone |
| Application: | Ezetimibe isomer |
| CAS | 1798008-25-9 |
| MW: | 409.4 D |
From 169.00€
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NPC1-like intracellular cholesterol transporter 1...
Item number: CSB-EP890689HUl1.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 22-284aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged and C-terminal HA-tagged. Target Protein Sequence: EPYTTIHQPG YCAFYDECGK NPELSGSLMT LSNVSCLSNT PARKITGDHL ILLQKICPRL YTGPNTQACC SAKQLVSLEA SLSITKALLT RCPACSDNFV NLHCHNTCSP...
| Keywords: | Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1, Recombinant Human NPC1-like... |
| Application: | Activity not tested |
| Expressed in: | E.coli |
| Origin: | human |
| MW: | 33.1 kD |
From 364.00€
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Human NPC1L1 Protein, His Tag
Item number: DIM-PME100720.10
Recombinant human NPC1L1 protein with C-terminal 6×His tag. NPC1L1(Glu22-Ser284) 6×His tag, Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that...
| Keywords: | NPC1-like intracellular cholesterol transporter 1, Niemann-Pick C1-like protein 1 |
| Expressed in: | Human cells |
| Origin: | human |
| CAS | 12 |
| MW: | 28.8 kD |
From 114.00€
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NPC1L1 (human) full length protein-synthetic nanodisc
Item number: DIM-FLP100089.10
Discover a breakthrough in membrane protein research and drug development with DIMA Biotech's Synthetic Nanodiscs. Traditional methods struggle with challenges in obtaining water-soluble and bioactive forms of multi-transmembrane proteins. Our innovative polymer-based Nanodisc platform offers a game-changing...
| Keywords: | Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1, LDLCQ7, NPC11L1, SLC65A2, Human... |
| Application: | Full length transmembrane protein, FA, ELISA, screening, immunization, cell-based assays, crystallization |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | 148.7 kD |
From 1,317.00€
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Anti-NPC1L1 Recombinant Monoclonal, clone 4B10
Item number: CSB-RA921474A0HU.100
Isotype: Rabbit IgG. Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity-chromatography. Target Name: NPC1L1. Antigen Species: Human
| Keywords: | Anti-Niemann-Pick C1-like protein 1, Anti-NPC1-like intracellular cholesterol transporter 1, NPC1-like intracellular... |
| Application: | ELISA, WB, IHC, FC |
| Host: | Rabbit |
| Species reactivity: | human |
From 201.00€
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![Anti-NPC1L1 [R09-2H3] Monoclonal Antibody](/custom/plugins/NetiThemeBiomol/Resources/Themes/Frontend/Biomol/frontend/_public/src/img/no-picture.jpg "Anti-NPC1L1 [R09-2H3] Monoclonal Antibody")
Anti-NPC1L1 [R09-2H3] Monoclonal Antibody
Item number: G-AGMB04111.100
NPC1L1 Monoclonal Antibody from Assay Genie is a high quality antibody for research use only. Protein Function: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol...
| Keywords: | Anti-NPC1L1, Anti-Niemann-Pick C1-like protein 1, Anti-NPC1-like intracellular cholesterol transporter 1 |
| Application: | WB |
| Host: | Rabbit |
| Species reactivity: | human |
From 134.00€
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