21 products were found matching "K14461"!

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 22-284aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged and C-terminal HA-tagged. Target Protein Sequence: EPYTTIHQPG YCAFYDECGK NPELSGSLMT LSNVSCLSNT PARKITGDHL ILLQKICPRL YTGPNTQACC SAKQLVSLEA SLSITKALLT RCPACSDNFV NLHCHNTCSP...

Recombinant human NPC1L1 protein with C-terminal 6×His tag. NPC1L1(Glu22-Ser284) 6×His tag, Protein function: Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that...

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Isotype: Rabbit IgG. Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Affinity-chromatography. Target Name: NPC1L1. Antigen Species: Human

Ezetimibe is an inhibitor of NPC1-like intracellular cholesterol transporter 1 (NPC1L1, Ki = 220 nM), a cholesterol transporter found in the apical membrane of enterocytes. It reduces cholesterol absorption in hamsters fed a high-cholesterol diet (ED50 = 0.04 mg/kg per day). Ezetimibe (346 nM) also reduces the...

Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe (Cay-16331) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of...

Ezetimibe is an anti-hyperlipidemic medication which is used to lower cholesterol levels. Specifically, it appears to bind to a critical mediator of cholesterol absorption, the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells as well as in hepatocytes.

3'-(2-Fluorophenyl) ezetimibe is an isomer of the cholesterol transport inhibitor ezetimibe (Cay-16331).Formal Name: (3S,4R)-rel-1-(4-fluorophenyl)-3-[(3R)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone. CAS Number: 1798008-25-9. Molecular Formula: C24H21F2NO3. Formula Weight: 409.4. Purity:...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Niemann-Pick C1-Like 1 (NPC1L1) is a protein found on the gastrointestinal tract epithelial cells as well as in hepatocytes. The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a...

Length: 3999 Sequence: atggcggagg ccggcctgag gggctggctg ctgtgggccc tgctcctgcg cttggcccag agtgagcctt acacaaccat ccaccagcct ggctactgcg ccttctatga cgaatgtggg aagaacccag agctgtctgg aagcctcatg acactctcca acgtgtcctg cctgtccaac acgccggccc gcaagatcac aggtgatcac ctgatcctat tacagaagat ctgcccccgc ctctacaccg gccccaacac...

Protein function: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....