25 products were found matching "K13700"!

WWL70 is an inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6, IC50 = 70 nM). It increases the expression of the adipose browning-related gene Ucp1 in differentiated 3T3-L1 mouse adipocytes and increases the oxygen consumption rate (OCR), an effect that can be blocked by the PPARalpha antagonist...

The serine hydrolase known as alpha/beta-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (2-AG, Cay-62160) to regulate its availability at cannabinoid receptors. KT195 is a selective inhibitor of ABHD6 (IC50 = 10 nM) with negligible activity against other serine hydrolases such as...

JZP 430 is an inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6, IC50 = 0.044 for the human enzyme). It is selective for ABHD6 over fatty acid amid hydrolase (FAAH) and monoacylglycerol lipase (MAGL) when used at a concentration of 2.5 µM, ABHD12 at 1 µM, as well as lysosomal acid lipase (LAL) and...

KT203 is a potent inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 0.82, 3.9, and 0.31 nM using Neuro2A membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2A cells in situ, respectively. Following administration of KT203 (1 mg/kg, i.p.) in mice, ABHD6 is...

KT182 is a potent inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with IC50 values of 1.7, 15.1, and 0.24 nM using Neuro2a membrane proteomes, recombinant ABHD6 in HEK293T cells, and Neuro2a cells in situ, respectively. Following administration of KT182 (1 mg/kg, i.p.) in mice, ABHD6 is...

The serine hydrolase known as alpha/beta-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol (Cay-62160) to regulate its availability at cannabinoid receptors. WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 µM) that demonstrates >10-fold selectivity for ABHD6 compared to a...

ABHD6 inhibitor.

KT185 is an orally bioavailable inhibitor of alpha/beta-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 0.21 nM in a competitive activity-based protein profiling assay using Neuro2A membranes. It inhibits ABHD6 in a 2-arachidonoyl glycerol (2-AG, Cay-62160) hydrolysis assay (IC50 = 13.6 nM for...

Protein function: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...

Description: KT182 is a selective and potent inhibitor of alpha/beta-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells. Target: MAGL. Smiles: OCc1cccc(c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1c1ccccc1. References: Hsu KL, et al. Discovery and optimization of piperidyl-1,2,3-triazole ureas...