- Search results for K12318
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31 products were found matching "K12318"!
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Item number: Cay81410-10
ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase. The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.Formal Name: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. CAS...
Keywords: | 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one |
Application: | Guanylyl cyclase inhibitor |
CAS | 41443-28-1 |
MW: | 187.2 D |
From 48.00€
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Item number: Cay16371-1
Soluble guanylate cyclase (sGC) is the primary cellular receptor for NO. NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cGMP. cGMP subsequently mediates a number of signaling cascades leading to vasorelaxation and inhibiting smooth muscle proliferation, leukocyte...
Keywords: | HMR 1766, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]-benzamide |
Application: | sGC, oxidized, heme-free, form, activator |
CAS | 254877-67-3 |
MW: | 576.5 D |
From 109.00€
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Item number: Cay9000554-10
Riociguat is a stimulator of soluble guanylate cyclase (sGC)., It stimulates recombinant sGC in a concentration-dependent manner in vitro by up to 73-fold when used at a concentration of 100 µM or by up to 112-fold when used in combination with the nitric oxide (NO) donor DEA NONOate (Cay-82100). It has no effect on...
Keywords: | BAY 63-2521, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbamic... |
Application: | Soluble guanylate cyclase activator |
CAS | 625115-55-1 |
MW: | 422.4 D |
From 114.00€
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Item number: Cay17468-1
Soluble guanylate cyclase (sGC) is the primary cellular receptor for NO. NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cGMP. cGMP subsequently mediates a number of signaling cascades leading to vasorelaxation and inhibiting smooth muscle proliferation, leukocyte...
Keywords: | BAY 58-2667, 4-[[(4-carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]-benzoic acid,... |
Application: | Soluble guanylate cyclase activator |
CAS | 646995-35-9 |
MW: | 602.2 D |
From 77.00€
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Item number: Cay81560-10
YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively. In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of...
Keywords: | 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol |
Application: | Platelet aggregation inhibitor |
CAS | 170632-47-0 |
MW: | 304.3 D |
From 24.00€
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Item number: Cay10011131-10
Soluble guanylate cyclase (sGC) is the primary cellular receptor for nitric oxide (NO). NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cyclic GMP (cGMP). BAY 41-8543 is a heme-dependent stimulator of sGC, increasing the activity of recombinant sGC...
Keywords: | 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine |
Application: | SGC stimulator |
CAS | 256498-66-5 |
MW: | 420.4 D |
From 44.00€
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Item number: Cay160895-1
Soluble guanylate cyclase is a heterodimeric enzyme, composed of alpha and beta subunits, that synthesizes cGMP from GTP. The enzyme is activated by the binding of nitric oxide or carbon monoxide to the heme group of the enzyme. Chronic hypoxia upregulates soluble guanylate expression in rat lung. The alpha1 subunit...
Keywords: | Anti-GUC1A3, Anti-GCS-alpha-1, Anti-GCS-alpha-3, Anti-GCS-alpha-1, Anti-GCS-alpha-3, Anti-Soluble guanylate cyclase large... |
Application: | WB, IHC |
Host: | Rabbit |
Species reactivity: | human |
422.00€
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Item number: Cay81600-10
NS 2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse...
Keywords: | 8-bromo-4H-2,5-dioxa-3,9b-diaza-cyclopenta[a]naphthalen-1-one |
Application: | Guanylyl cyclase inhibitor |
CAS | 204326-43-2 |
MW: | 269.1 D |
From 64.00€
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Item number: Cay10057-10
Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain. The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine...
Keywords: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine |
Application: | Soluble guanylate cyclase activator |
CAS | 256376-24-6 |
MW: | 360.4 D |
From 142.00€
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Item number: AG-CR1-0120-M025
Nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na channel blocker. Anticancer compound. HIF-alpha inhibitor....
Keywords: | 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole |
Application: | Soluble guanylyl cyclase (sGC) activator |
CAS | 170632-47-0 |
MW: | 304,4 D |
From 28.00€
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Item number: AG-CR1-3500-M010
Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC), The binding is competitive with nitric oxide (NO), Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
Keywords: | 1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one |
Application: | Soluble guanylyl cyclase inhibitor |
CAS | 41443-28-1 |
MW: | 187,2 D |
From 66.00€
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Item number: ARG56511.250
Keywords: | Anti-GUC1A3, Anti-GUCY1A3, Anti-GCS-alpha-3, Anti-GCS-alpha-1, Anti-Soluble guanylate cyclase large subunit,... |
Application: | WB |
Host: | Rabbit |
Species reactivity: | human, mouse, bovine |
656.00€
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