55 products were found matching "K12316"!

Description: Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits alpha- and beta-glucosidases, especially glucosidase l. Target: Glucosidase. Smiles: OC1CCN2CC(O)C(O)C(O)C12. References: Bryan G, Anthony C et al. The structural basis of the inhibition of human glycosidases...

Description: N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid alpha-glucosidase and alpha-1,6-glucosidase with IC50 values of 0.42 µM and 8.4 µM, respectively. Smiles: CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO. References: Andersson U, et al. Inhibition of glycogen breakdown by imino sugars in vitro and...

Description: 2,3-Indolobetulonic acid is pentacyclic triterpenoid derivative of betulonic acid and an inhibitor of alpha-glucosidase (IC50= 1.8 µM).1. Target: Others. Smiles: [H][C@]12[C@@H](CC[C@@]1(CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)Cc4c([nH]c5ccccc45)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O)C(C)=C. References:...

Description: 1-Deoxynojirimycin (Moranoline) is a potent alpha-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus. Target: Glucosidase, PI3K. Smiles: OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O. References: Jiang P, et al. Sci Rep. 2015 Feb 24,5:8563.

Description: 4-Methylumbelliferyl-alpha-D-glucopyranoside serves as a fluorogenic substrate for alpha-glucosidase, used in enzymatic assays. This compound undergoes cleavage by alpha-glucosidase, releasing 4-methylumbelliferyl (4-MU), a compound whose fluorescence intensity varies with pH. Specifically, 4-MU...

Glucosidases catalyze the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. Castanospermine is an inhibitor of both alpha- and beta-glucosidases, inhibiting lysosomal and neutral alpha-glucosidases with Ki values of 0.1 and 10 µM, respectively,...

Miglitol is an inhibitor of alpha-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 µM for human lysosomal alpha-glucosidase and rat sucrase, maltase, and isomaltase, respectively). It is selective for human alpha- over beta-glucosidase (IC50 = 84 µM). Miglitol (10 mg/kg) decreases blood glucose levels in...

White solid. Soluble in water or DMSO. Anti-diabetic agent with antihyperglycemic activity. alpha-Glucosidase inhibitor. Inhibits lysosomal alpha-glucosidase, sucrase, maltase and isomaltase (IC50= 0.35, 0.11, 1.3, and 1.2&mu,M, respectively) as well as maltase-glucoamylase (IC50 = 1.0&mu,M), alpha-Glucosidase...

Soluble in DMSO or water. Isolated from Streptomyces sp. Polyhydroxylated piperidine alkaloid. alpha-Glucosidase I and II inhibitor. Antidiabetic. Antihyperglycaemic activity. Animal feedstuff additive. Antiviral. Shows anti-HIV activity.

Ex: 571 nm. Em: 585 nm. Soluble in: DMSO. Resorufin alpha-D-glucopyranoside is a sensitive fluorogenic substrate that generates a red fluorescent product (resorufin) upon interaction with alpha-glucosidase. It is used for measuring alpha-glucosidase activities and high throughput screening of alpha-glucosidase...