61 products were found matching "K12316"!

An isoindolinone with diverse biological activities, inhibits alpha-glucosidase (IC50 = 5.3 µM), cytotoxic to A549 and HeLa cancer cells (IC50s = 49 and 40.5 µM, respectively), induces neurite outgrowth in Neuro2a cells at 25 µM, increases NGF production in C6 cells at 50 µM. Formulation: A solid. InChI:...

Glucosidases catalyze the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. Castanospermine is an inhibitor of both alpha- and beta-glucosidases, inhibiting lysosomal and neutral alpha-glucosidases with Ki values of 0.1 and 10 µM, respectively,...

Miglitol is an inhibitor of alpha-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 µM for human lysosomal alpha-glucosidase and rat sucrase, maltase, and isomaltase, respectively). It is selective for human alpha- over beta-glucosidase (IC50 = 84 µM). Miglitol (10 mg/kg) decreases blood glucose levels in...

White solid. Soluble in water or DMSO. Anti-diabetic agent with antihyperglycemic activity. alpha-Glucosidase inhibitor. Inhibits lysosomal alpha-glucosidase, sucrase, maltase and isomaltase (IC50= 0.35, 0.11, 1.3, and 1.2&mu,M, respectively) as well as maltase-glucoamylase (IC50 = 1.0&mu,M), alpha-Glucosidase...

Soluble in DMSO or water. Isolated from Streptomyces sp. Polyhydroxylated piperidine alkaloid. alpha-Glucosidase I and II inhibitor. Antidiabetic. Antihyperglycaemic activity. Animal feedstuff additive. Antiviral. Shows anti-HIV activity.

Ex: 571 nm. Em: 585 nm. Soluble in: DMSO. Resorufin alpha-D-glucopyranoside is a sensitive fluorogenic substrate that generates a red fluorescent product (resorufin) upon interaction with alpha-glucosidase. It is used for measuring alpha-glucosidase activities and high throughput screening of alpha-glucosidase...

Voglibose is an inhibitor of alpha-glucosidases (IC50s = 5.6, 0.11, 0.16, and 0.07 µM for human lysosomal alpha-glucosidase and rat maltase, isomaltase, and sucrase, respectively). It is selective for human alpha- over beta-glucosidase (IC50 = >1,000 µM). Voglibose (0.2 mg/kg) decreases body weight and food intake...

Protein function: Essential for the degradation of glycogen in lysosomes (PubMed:1856189, PubMed:7717400, PubMed:14695532, PubMed:18429042). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980). [The UniProt Consortium]

4-Methylumbelliferyl-alpha-D-glucopyranoside is a fluorogenic substrate for alpha-glucosidase. 4-Methylumbelliferyl-alpha-D-glucopyranoside is cleaved by alpha-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low...

Protein function: Essential for the degradation of glycogen in lysosomes (PubMed:1856189, PubMed:7717400, PubMed:14695532, PubMed:18429042). Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980). [The UniProt Consortium]