144 products were found matching "K11988"!

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of...

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Zebrafish Shha, also known as sonic hedgehog a, is a signaling molecule that plays a critical role in embryonic development, pattern formation, and cell differentiation. Shha belongs to the hedgehog family of secreted proteins that regulate key developmental...

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of...

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 0.05 µM). It is selective for COX-2 over COX-1 (IC50 = 22.9 µM). Celecoxib induces apoptosis in BJAB and Jurkat cancer cells in a concentration-dependent manner. It reduces blood glucose levels in a rat model of diabetes induced...

Mouse sonic hedgehog (mShh), also known as HHG-1. GenBank Accession No. NM_009170, a.a. 25-198 with a C-terminal His-tag, expressed in an E. coli cell expression system, MW = 20.5 kDa.

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development. Shh binds to its receptor, Patched (Ptch1), resulting in the de-repression of Smoothened. This leads to the activation of Gli2, which regulates the transcription of...

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet. It potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC50 = 140 nM). Zerumbone inhibits Sonic hedgehog signaling and induces apoptosis in cancer cell lines. It has also been shown to...

Sonic Hedgehog purity was determined to be greater than 97% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE. Protein function: Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral...

SANT-2 is a Smoothened (Smo) receptor antagonist. It binds to the Smo receptor (Kd = 12 nM) and inhibits binding of the Smo receptor agonist SAG-1.3 (SAG, Cay-11914) and antagonist cyclopamine (Cay-11321) (Kis = 7.8 and 8.4 nM, respectively). SANT-2 inhibits hedgehog signaling induced by an N-terminal fragment of...

Sonic hedgehog (Shh) signaling small molecule modulator , Inhibits the Shh pathway in human cell lines upstream of Smo, Targets the Shh N-terminal protein.

Cell permeable low toxicity Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Potent activator of VEGF expression in vitro.