28 products were found matching "K11833"!

The DUB-Freedom(TM) Inhibitor Screening Assay Kit is a fluorogenic assay designed to measure the activity of several purified deubiquitinating (DUB) enzymes of interest in a homogeneous 96-reaction format and is ideal for screening and profiling applications. The kit contains enough Ubiquitinated-AMC substrate and...

The Ubiquitin specific peptidase 2 (USP2) Inhibitor Screening Assay Kit is a homogeneous fluorogenic assay designed to measure the activity of the deubiquitinating (DUB) enzyme USP2 for screening and profiling applications. The kit contains enough purified USP2 recombinant protein, Ubiquitinated-AMC substrate, and...

Ubiquitin-specific protease 2 (USP2), also known as ubiquitin carboxyl-terminal hydrolase 2, is a cysteine protease involved in intracellular protein degradation by deubiquitinating degraded protein, including Mdm2, Mdm4, and CCND1. In both normal and cancer cells, it regulates G1/S cell-cycle transition. It may...

Human USP2 (Ubiquitin-Specific Protease 2) or UPB41, GenBank Accession No. NM_004205, amino-acids 2-605(end) with an N-terminal FLAG-tag, MW=68 kDa, expressed in a baculovirus-infected Sf9 cell expression system.

Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2...

ML-364 is a reversible inhibitor of ubiquitin-specific protease 2 (USP2), a deubiquitinase, that has an IC50 value of 1.1 µM in a fluorescence-based assay using di-ubiquitin substrates. It inhibits USP8, which is closely related to USP2, with an IC50 value of 0.95 µM in the same assay. It has no activity at the...

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates...

USP2 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human, Mouse, Rat and for use in ELISA, IHC applications. USP2 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2,...

USP2 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human, Mouse, Rat and for use in ELISA, IHC applications. USP2 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2,...

USP2 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, IHC applications. USP2 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1...

USP2 Antibody is a IgG polyclonal antibody from Assay Genie with reactivity against Human and for use in ELISA, IF applications. USP2 Antibody is a high quality polyclonal antibody for research use only.. Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1...

Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated...