22 products were found matching "K11724"!

Description: ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS. Target: Epigenetic Reader Domain, HIV Protease. Smiles: CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cc(F)cc1C)C(C)(C)O. References: Emily J....

Description: BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraception, cancer, and heart disease [1]. Target: Epigenetic Reader Domain. Smiles: CN1C(=O)N(C)C2=C(C(C3=C(COC3=O)N2)C2=CC=C(C)C=C2)C1=O

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1...

ABBV-744 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2, Kis = 4.6, 4.9, 1.6, and 1 nM for BRD2, -3, -4, and -T, respectively). It is selective for BD2 over BD1 bromodomains in a time-resolved FRET (TR-FRET) assay (Kis = 1,162, 3,140, 521, and 917 nM for BRD2,...

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9, amino-acids 257 ? 382 (GenBank Accession No. NM_207189) with N-terminal GST tag, MW = 41.7 kDa, expressed in an E. coli expression system.

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9, amino-acids 22 ? 382 (GenBank Accession No. NM_207189) with N-terminal GST tag, MW = 68.1 kDa, expressed in an E. coli expression system.

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9, amino-acids 257-382 (GenBank Accession No. NM_207189) with N-terminal HIS tag, MW = 15.8 kDa, expressed in an E. coli expression system.

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9, amino-acids 22-138 (GenBank Accession No. NM_207189) with N-terminal HIS tag, MW = 14.9 kDa, expressed in an E. coli expression system.

Human Bromodomain testis-specific protein, also known as BRDT, BRD6, and CT9, amino-acids 22 ? 138 (GenBank Accession No. NM_207189) with N-terminal GST tag, MW = 40.7 kDa, expressed in an E.coli expression system.

Protein function: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated...

In 1X PBS, pH 7.4, with 0.09% sodium azide. BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in...

Key Features Cayman's BRDT bromodomain 1 TR-FRET Assay Kit (Cay-600650) was developed using BRDT bromodomain 1 (human, recombinant) protein.Bulk sizes available upon request The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues...