44 products were found matching "K11427"!
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Human DOT1L (DOT1 Like, Histone H3 Methyltransferase)...
Item number: ELK-ELK7502.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DOT1L. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DOT1L. Next,...
| Keywords: | KIAA1814, H3-K79-HMTase, DOT1-like protein, Lysine N-methyltransferase 4, Histone H3-K79 methyltransferase, Histone-lysine... |
| Application: | ELISA |
| Species reactivity: | human |
From 365.00€
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EPZ5676
Item number: Cay16175-1
DOT1L is a non-SET domain containing methyltransferase whose function is important for the transcriptional activation of certain genes, DNA damage repair, and cell cycle regulation. DOT1L is known to play an essential role in MLL-rearranged leukemias, and thus has emerged as a drug target for these leukemias....
| Keywords: | 9-[5-deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-beta-D-ribofura... |
| Application: | DOT1L inhibitor |
| CAS | 1380288-87-8 |
| MW: | 562.7 D |
From 60.00€
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SGC0946
Item number: Cay13967-10
DOT1L is a protein methyltransferase (PMT). It is the only enzyme known to methylate histone 3 at lysine 79 (H3K79), where it catalyzes mono-, di-, and trimethylation. Proper DOT1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation. SGC0946 is a potent...
| Keywords: | 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofura... |
| Application: | Potent DOT1L inhibitor |
| CAS | 1561178-17-3 |
| MW: | 618.6 D |
From 129.00€
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EPZ004777 (formate)
Item number: Cay16173-1
EPZ004777 is a potent inhibitor of DOT1L (IC50 = 400 pM) that selectively kills mixed lineage leukemia (MLL) cells in vitro and prolongs survival in an MLL xenograft mouse model. It displays >1,000-fold selectivity for DOT1L relative to a panel of histone methyltransferases. DOT1L inhibition by EPZ004777 has also...
| Keywords: | 7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7... |
| Application: | DOT1L inhibitor |
| MW: | 585.7 D |
From 43.00€
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Anti-DOT1L
Item number: A300-954A
Protein function: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [The UniProt Consortium]
| Keywords: | Anti-DOT1L, Anti-KIAA1814, EC=2.1.1.43, Anti-H3-K79-HMTase, Anti-DOT1-like protein, Anti-Lysine N-methyltransferase 4,... |
| Application: | WB, IP |
| Host: | Rabbit |
| Species reactivity: | human |
From 164.00€
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Anti-DOT1L
Item number: A300-953A
Protein function: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [The UniProt Consortium]
| Keywords: | Anti-DOT1L, Anti-KIAA1814, EC=2.1.1.43, Anti-H3-K79-HMTase, Anti-DOT1-like protein, Anti-Lysine N-methyltransferase 4,... |
| Application: | WB, IP, IHC, ChIP-Seq |
| Host: | Rabbit |
| Species reactivity: | human |
From 164.00€
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EPZ-5676
Item number: LKT-E6398.5
EPZ-5676 is an inhibitor of DOT1L histone methyltransferase (HMT) that exhibits anticancer chemotherapeutic activity. In acute myelogenous leukemia (AML) cells with MLL gene translocations, EPZ-5676 displays cytotoxicity, in similar animal models, this compound induces tumor regression without toxicity.
| Application: | DOT1L inhibitor |
| CAS | 1380288-87-8 |
| MW: | 562.71 D |
From 229.00€
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EPZ004777
Item number: BPS-27622
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 400 pM. EPZ004777 selectively kills a variety of MLL-rearranged leukemia cells, including an MLL-AF4 leukemia cell line MV4-11 and an MLL-AF9 leukemia cell line MOLM13.
| Keywords: | 1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4... |
| Application: | DOT1L inhibitor |
| MW: | 539.7 D |
434.00€
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DOT1L Chemiluminescent Assay Kit
Item number: BPS-52202
The DOT1L Chemiluminescent Assay Kit is designed to measure DOT1L activity for screening and profiling applications. The key to the DOT1L Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated K79 residue of H3. With this kit, only three simple steps on a microtiter plate are required...
| Keywords: | KMT4, KIAA1814, |
| Application: | Enzyme kinetics, HTS |
| Species reactivity: | human |
1,101.00€
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Anti-KMT4
Item number: NSJ-F53487-0.4ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. KMT4 is a histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [UniProt] Protein function: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as...
| Keywords: | Anti-DOT1L, Anti-KIAA1814, EC=2.1.1.43, Anti-H3-K79-HMTase, Anti-DOT1-like protein, Anti-Lysine N-methyltransferase 4,... |
| Application: | IHC, ELISA |
| Host: | Rabbit |
| Species reactivity: | human |
702.00€
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Anti-DOT1L (IHC)
Item number: IHC-00494
Protein function: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. [The UniProt Consortium]
| Keywords: | Anti-DOT1L, Anti-KIAA1814, EC=2.1.1.43, Anti-H3-K79-HMTase, Anti-DOT1-like protein, Anti-Lysine N-methyltransferase 4,... |
| Application: | IHC |
| Host: | Rabbit |
| Species reactivity: | human |
From 164.00€
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EPZ5676
Item number: BPS-27625-1
EPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM.
| Keywords: | (2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl... |
| Application: | DOT1L inhibitor |
| MW: | 562.7 D |
From 497.00€
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