75 products were found matching "K11404"!

Active complex of human HDAC3 , GenBank Accession No. NM_003883, full length with C-terminal His tag, MW= 49.7 kDa, and human NCOR2 , amino acid 395- 489, GenBank Accession No. NM_006312, N-terminal GST tag, MW= 37.6 kDa, co-expressed in baculovirus expression system.

Apicidin is a cyclic tetrapeptide that has been found in F. pallidoroseum and has diverse biological activities. It is active against E. tenella, T. gondii, P. falciparum, C. parvum, N. caninum, B. jellisoni, and C. bigenetica (MICs = 62, 8, 125, 30, 15, 4, and 8 ng/ml, respectively) and decreases the percentage of...

HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM. At 10 mg/kg, RGFP966 can facilitate the extinction of...

Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to HDAC3/Histone deacetylase 3. Protein function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates...

Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent and selective inhibition of HDAC1, 2, 3, and 8 (IC50s =...

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle...

The Fluorogenic HDAC3 Assay Kit is a complete assay system designed to measure HDAC3 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent HDAC3 activity measurements. In addition, the kit includes purified HDAC3 enzyme and the...

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3, Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s...

RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs, IC50s = 60 and 50 nM, Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively). It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich's ataxia patients and in a GAA repeat-based mouse...

PCI 24781 is an HDAC inhibitor that predominantly targets HDAC1 with a Ki value of 7 nM. It inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 with Ki values of 19, 8.2, 17, 280, and 24 nM, respectively. PCI 24781 can prevent the growth of tumor cells in vitro, inducing apoptosis, as well as in mice harboring...

BRD3308 is an inhibitor of histone deacetylase 3 (HDAC3, Ki = 29 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (Kis = 6,300 and 5,100 nM, respectively). BRD3308 (10 µM) reduces cytokine-induced increases in apoptosis in rat INS-1E beta cells. In vivo, BRD3308 (5 mg/kg) reduces plasma glucose levels in rats and...

Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...