The following products have been found matching your search "K11404": 59

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Apicidin
Apicidin

Item number: Cay10575-1

Histone acetyltransferase and histone deacetylase (HDAC) activity regulates the reversible acetylation of lysine residues within histone tails, which results in either transcriptional activation or repression of nearby genes. Compounds that modulate this activity are of interest in cancer chemotherapeutics as well...
Keywords: OSI 2040, cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
Application: HDAC inhibitor
CAS 183506-66-3
MW: 623.8 D
From 59.00€ *
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RGFP966
RGFP966

Item number: Cay16917-1

HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM. At 10 mg/kg, RGFP966 can facilitate the extinction of...
Keywords: (2E)-N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Application: HDAC3 inhibitor
CAS 1357389-11-7
MW: 362.4 D
From 32.00€ *
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HDAC-3/NcoR2 Complex, active human recombinant proteins
HDAC-3/NcoR2 Complex, active human recombinant proteins

Item number: BPS-50003

Active complex of human HDAC3 , GenBank Accession No. NM_003883, full length with C-terminal His tag, MW= 49.7 kDa, and human NCOR2 , amino acid 395- 489, GenBank Accession No. NM_006312, N-terminal GST tag, MW= 37.6 kDa, co-expressed in baculovirus expression system.
Keywords: Histone Deacetylase-3, HDAC3/NcoR-2 HD3, HDAC3, RPD3-2, SMAP45, EC=3.5.1.98, Histone deacetylase 3
Application: Enzyme kinetics, inhibitor screening
556.00€ *
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Panobinostat
Panobinostat

Item number: Cay13280-25

Panobinostat is a potent inhibitor of all histone deacetylases (HDACs), with Ki values ranging from 0.6 to 31 nM for HDAC1-11. Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells. It has potential applications in several different...
Keywords: LBH-589, (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide
Application: HDAC inhibitor
CAS 404950-80-7
MW: 349.4 D
From 62.00€ *
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Anti-HDAC3
Anti-HDAC3

Item number: A300-464A

Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle...
Keywords: Anti-HD3, Anti-HDAC3, Anti-SMAP45, Anti-RPD3-2, EC=3.5.1.98, Anti-Histone deacetylase 3
Application: WB, IP, IHC
Reactivity: Human, Mouse
From 125.00€ *
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Romidepsin
Romidepsin

Item number: Cay17130-5

Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent and selective inhibition of HDAC1, 2, 3, and 8 (IC50s =...
Keywords: FK228, FR901228, Istodax(R), NSC 630176, cyclic...
Application: Class I HDAC inhibitor
CAS 128517-07-7
MW: 540.7 D
From 112.00€ *
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HDAC3 Fluorogenic Assay kit
HDAC3 Fluorogenic Assay kit

Item number: BPS-50073

The Fluorogenic HDAC3 Assay Kit is a complete assay system designed to measure HDAC3 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent HDAC3 activity measurements. In addition, the kit includes purified HDAC3 enzyme and the...
Keywords: HD3, HDAC3, RPD3-2, SMAP45, EC=3.5.1.98, Histone deacetylase 3
Application: HDAC3 activity screening
562.00€ *
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RGFP109
RGFP109

Item number: Cay21568-5

RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs, IC50s = 60 and 50 nM, Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively). It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich's ataxia patients and in a GAA repeat-based mouse...
Keywords: RG-2833, N-[6-[(2-aminophenyl)amino]-6-oxohexyl]-4-methyl-benzamide
Application: Brain-penetrant HDAC inhibitor
CAS 1215493-56-3
MW: 339.4 D
From 62.00€ *
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PCI 24781
PCI 24781

Item number: Cay20059-1

PCI 24781 is an HDAC inhibitor that predominantly targets HDAC1 with a Ki value of 7 nM. It inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 with Ki values of 19, 8.2, 17, 280, and 24 nM, respectively. PCI 24781 can prevent the growth of tumor cells in vitro, inducing apoptosis, as well as in mice harboring...
Keywords: CRA-024781, CRA-24781, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
Application: Antineoplastic, HDAC inhibitor
CAS 783355-60-2
MW: 397.4 D
From 32.00€ *
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PAOA
PAOA

Item number: Cay22942-5

PAOA is a selective histone deacetylase (HDAC) inhibitor with IC50 values of 199 and 69 nM for HDAC1 and HDAC3, respectively. It is selective for HDAC1 and HDAC3, having IC50 values greater than 1.59 µM for HDAC2, 4, 5, 7, and 8 in a cell-free enzyme assay. In vitro, PAOA induces histone H3 and H4 hyperacetylation....
Keywords: Histone Deacetylase Inhibitor IV, N1-(2-aminophenyl)-N7-phenyl-heptanediamide
Application: HDAC1 / HDAC3 inhibitor
CAS 537034-15-4
MW: 325.4 D
From 94.00€ *
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MI-192
MI-192

Item number: Cay18288-1

MI-192 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC2 (IC50 = 30 nM) and HDAC3 (IC50 = 16 nM) over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 µM, respectively). At 0.1-0.4 µM, it induces differentiation and promotes apoptosis of acute myeloid leukemic cell lines...
Keywords: N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide
Application: HDAC2/3 inhibitor
CAS 1415340-63-4
MW: 383.4 D
From 44.00€ *
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HDAC3 Inhibitor
HDAC3 Inhibitor

Item number: Cay21057-1

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3, Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s...
Keywords: Histone Deacetylase 3, 4-[[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]amino]methyl]-benzoic acid 2-propylhydrazide
Application: Histone deacetylase 3 (HD3) inhibitor
CAS 2044701-99-5
MW: 337.4 D
From 49.00€ *
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