67 products were found matching "K11219"!

Cenacitinib is an inhibitor of tyrosine kinase 2 (TYK2). Formal Name: N-[(1R,2S)-2-fluorocyclopropyl]-N'-[5-[(7-fluoro-2,3-dihydro-1,4-benzodioxin-5-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidin-3-yl]-urea. CAS Number: 2641636-52-2. Molecular Formula: C19H19F2N7O3. Formula Weight: 431.4. Purity: >98%....

Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that play an important role in cytokine-mediated signaling. This family includes four protein kinases, Jak1, Jak2, Jak3 and Tyk2. Various studies have suggested that regulation of Jak activity should be a promising approach to combat...

Human Tyrosine Kinase 2 (TYK2), also known as JTK1, IMD35, and Non-Receptor Tyrosine-Protein Kinase TYK2, Genbank Accession No. NM_003331, a.a. 575-869 with N-terminal FLAG-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 34 kDa.

TC JL 37 is an inhibitor of tyrosine kinase 2 (TYK2, Ki = 1. nM). It inhibits IL-12-induced phosphorylation of STAT4 in cells and IL-12- and IL-18-induced IFN-gamma production in isolated human peripheral blood mononuclear cells (PBMCs, EC50s = 224 and 168 nM, respectively). TC JL 37 (10-100 mg/kg) inhibits IL-12-...

RO495 is a tyrosine kinase 2 (TYK2) inhibitor.. Solulibility: DMSO: Soluble: = 10 mg/ml: Ethanol: Sparingly soluble: 1-10 mg/ml.

BMS 986165 is an allosteric inhibitor of tyrosine kinase 2 (TYK2, IC50 = 0.2 nM for the recombinant TYK2 pseudokinase domain). It is selective for TYK2 over a panel of 249 protein and lipid kinases at 1 µM but does inhibit the JAK1 pseudokinase domain and bone morphogenetic protein receptor type II (BMPR2, IC50s = 1...

Cerdulatinib is a dual inhibitor of spleen tyrosine kinase (Syk) and Janus kinases (JAK, IC50s = 32, 12, 6, 8, and 0.5 nM for Syk, JAK1, JAK2, JAK3, and TYK2, respectively) and also exhibits nanomolar inhibition of other kinases. Syk is involved in the B cell receptor (BCR) pathway, and cerdulatinib inhibits...

Peficitinib is an inhibitor of JAK (IC50s = 3.9, 5, and 0.71 nM for JAK1-3, respectively). It is 14-fold selective for JAK1 and JAK3 over JAK2 in erythropoietin-induced leukemia cell proliferation assays. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC50 = 10 nM) and phosphorylation of STAT5...

Active recombinant human Tyk2 (Tyrosine Kinase 2, alsoknown as JTK1), GenBank Accession No. NM_003331, a.a. 871-1187(end), with N-terminal His-tag, MW=38 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

Soluble in DMSO. Bayer-18 is a selective TYK2 inhibitor, with an IC(50) of 18.7nM on TYK2 as measured by TYK2 HTRF assays. The compound shows 1000 fold selectivity against JAK2, CDK and KDR kinases in similar HTRF assays. Target: TYK2 , Kinase Group: RTK , Substrate: Tyrosine

Soluble in DMSO. RO495 is a very potent TYK2 inhibitor with a IC(50) of 1.5nM on TYK2 as tested in cell-based pharmacological assays including the compound-mediated effects on STAT5 phosphorylation in Set-2 lysates or IL-12 stimulation of NK92 using the Meso Scale Discovery (MSD) technology. Target: TYK2 , Kinase...

PF-06700841 is an inhibitor of JAK1 and tyrosine kinase 2 (TYK2, IC50s = 17 and 23 nM, respectively). It is selective for JAK1 and TYK2 over JAK2 and JAK3 (IC50s = 77 and 6,494 nM, respectively). PF-06700841 selectively inhibits IFN-alpha/STAT3 signaling over erythropoietin/STAT5 signaling in human whole blood...