17 products were found matching "K11160"!

PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2, IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 µM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent...

Protein function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Diacylglycerol O-acyltransferase-like protein 2 Protein function: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DGAT2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DGAT2. Next,...

Description: PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate,...

Description: Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH). Target: Transferase. Smiles: O(C1=CC(C=2N=CC(C(N[C@H]3CCOC3)=O)=CN2)=CN=C1)C4=C(OCC)C=CC=N4....

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human DGAT2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human DGAT2. Next,...

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high...

Acyl-CoA:diacylglycerol acyltransferase, or DGAT (EC 2.3.1.20), is responsible for the synthesis of triglycerides. It catalyzes a reaction in which diacylglycerol is covalently joined to long chain fatty acyl-CoAs. Applications: Suitable for use in Western Blot and ELISA. Other applications have not been tested. ,...

Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) BioAssay(TM) ELISA Kit (Human) is a sandwich enzyme immunoassay for the in vitro quantitative measurement of human DGAT2 in tissue homogenates and other biological fluids. Detection Range: 13.7-10,000pg/ml, Sensitivity: 7.1pg/ml, Storage and Stability: Desiccation...

ELISA Type: Sandwich ELISA, Double Antibody. Detection Range: 31.25-2000µg/mL. Sensitivity: 18.75µg/mL. Sample Types: Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples. Protein function: Essential acyltransferase that catalyzes the terminal and only committed step in...

Length: 1167 Sequence: atgaagaccc tcatagccgc ctactccggg gtcctgcgcg gcgagcgtca ggccgaggct gaccggagcc agcgctctca cggaggacct gcgctgtcgc gcgaggggtc tgggagatgg ggcactggat ccagcatcct ctccgccctc caggacctct tctctgtcac ctggctcaat aggtccaagg tggaaaagca gctacaggtc atctcagtgc tccagtgggt cctgtccttc cttgtactgg gagtggcctg...