Anthrax is an infectious disease due to Bacillus anthracis, a gram-positive, spore-forming bacterium. Among bioterrorist agents, anthrax is considered as one of the most potent and dangerous bio-agent and has been classifi ed in the A list of the Centers of Disease Control. The pathogenic power of this bacteria is...

Anti-Anthrax Edema Factor Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Anthrax Edema Factor from other sources has not been determined. Protein function: One of the three proteins composing the anthrax toxin, the agent which infects many mammalian...

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) (1,2 for review). PA binds to two related proteins on the...

Anthrax edema factor (EF) is a component of edema toxin (EdTx) produced by B. anthracis. It is comprised of an N-terminal protective antigen (PA) binding domain (PABD), an adenylyl cyclase domain, and a helical domain. Inactive EF binds oligomerized B. anthracis PA on the host cell surface. EF and PA, together known...