43 products were found matching "K10807"!

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Human RRM1 (Ribonucleotide Reductase M1) ELISA Kit
Human RRM1 (Ribonucleotide Reductase M1) ELISA Kit

Item number: ELK-ELK3959.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human RRM1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human RRM1. Next,...
Keywords: RR1, RRM1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,...
Application: ELISA
Species reactivity: human
365.00€ * From 328.50€ *
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Mouse RRM1 (Ribonucleotide Reductase M1) ELISA Kit
Mouse RRM1 (Ribonucleotide Reductase M1) ELISA Kit

Item number: ELK-ELK7025.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse RRM1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse RRM1. Next,...
Keywords: Rrm1, EC=1.17.4.1, Ribonucleotide reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1,...
Application: ELISA
Species reactivity: mouse
365.00€ * From 328.50€ *
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LY2334737
LY2334737

Item number: Cay37425-1

LY2334737 is a prodrug form of the nucleoside analog gemcitabine (Cay-11690, Cay-9003096). In vivo, LY2334737 (8 mg/kg) reduces tumor volume in an MDA321-LM2-4175 breast cancer mouse xenograft model and increases survival in an SKOV3 ovarian cancer mouse xenograft model.Formal Name:...
Keywords: 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)-cytidine
Application: Gemcitabine prodrug form
CAS 892128-60-8
MW: 389.4 D
From 35.00€ *
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Gemcitabine
Gemcitabine

Item number: Cay11690-10

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate (Cay-31726) and the...
Keywords: DDFC, LY 188011, NSC 613327, 2'-deoxy-2',2'-difluoro-cytidine
Application: Antiretroviral activity, Apoptosis inducer
CAS 95058-81-4
MW: 263.2 D
From 68.00€ *
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Cladribine
Cladribine

Item number: Cay12085-10

Cladribine is a nucleoside analog of deoxyadenosine and prodrug form of 2-chlorodeoxyadenosine triphosphate (2-CdATP). It is triphosphorylated to Cd-ATP by the successive actions of deoxycytidine kinase, nucleoside monophosphate kinase, and nucleoside diphosphate kinase. Cladribine is cytotoxic to resting or...
Keywords: 2-Chlorodeoxyadenosine, Biodribin, Jk 6251, Leustatin, NSC 105014, RWJ 26251, 2-chloro-2'-deoxy-adenosine
Application: Nucleoside analog, Lymphocyte cytotoxic
CAS 4291-63-8
MW: 285.7 D
From 30.00€ *
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Clofarabine
Clofarabine

Item number: Cay14125-5

Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-alpha (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial...
Keywords: Clolar, Evoltra, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
Application: Ribonucleotide reductase and DNA polymerase-alpha Inhibitor
CAS 123318-82-1
MW: 303.7 D
From 52.00€ *
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2',2'-Difluoro-2'-deoxyuridine
2',2'-Difluoro-2'-deoxyuridine

Item number: Cay11689-5

2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine (Cay-11690). It is formed by deamination of gemcitabine by cytidine deaminase in the liver. 2',2'-Difluoro-2'-deoxyuridine is cytotoxic to HepG2 and A549 cancer cells (IC50s = 3.13 and 3.92 µM, respectively). It...
Keywords: dFdU, 2'-deoxy-2',2'-difluoro-uridine
Application: Gemcitabine active metabolite
CAS 114248-23-6
MW: 264.2 D
From 66.00€ *
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Gemcitabine-13C,15N2 (hydrochloride)
Gemcitabine-13C,15N2 (hydrochloride)

Item number: Cay22560-1

Gemcitabine-13C,15N2 is intended for use as an internal standard for the quantification of gemcitabine (Cay-11690, Cay-9003096) by GC- or LC-MS. Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 (Cay-9003247) and gemcitabine elaidate (Cay-28303) and a prodrug form of gemcitabine di- and...
Keywords: 2'-deoxy-2',2'-difluoro-cytidine-2-13C-1,3-15N2, monohydrochloride
Application: GC-MS, LC-MS, internal standard, apoptosis inducer, RRM1 inhibitor
CAS 2757566-59-7
MW: 302.6 D
From 238.00€ *
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NUC-1031
NUC-1031

Item number: Cay9003247-1

NUC-1031 is a prodrug form of the anticancer nucleoside analog gemcitabine (Cay-11690). NUC-1031 is more lipophilic than gemcitabine and enters cells through passive diffusion. It inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50 = 35, 30, 60, and 40 nM, respectively). NUC-1031 (0.076...
Keywords: N-(2'-deoxy-2',2'-difluoro-P-phenyl-5'-cytidylyl)-L-alanine, phenylmethyl ester
Application: Gemcitabine prodrug
CAS 840506-29-8
MW: 580.5 D
From 50.00€ *
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Gemcitabine Elaidate
Gemcitabine Elaidate

Item number: Cay28303-1

Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine (Cay-11690, Cay-9003096) that contains an elaidic acid (Cay-90250) moiety. Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not...
Keywords: CP 4126, 2'-deoxy-2',2'-difluoro-cytidine, 5'-(9E)-9-octadecenoate
Application: Lipophilic gemcitabine prodrug, antineoplastic, antimetabolite
CAS 210829-30-4
MW: 527.6 D
From 43.00€ *
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Anti-RRM1
Anti-RRM1

Item number: ARG55465.100

Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [The UniProt Consortium]
Keywords: Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase...
Application: WB, ICC, IF
Host: Rabbit
Species reactivity: human, mouse
624.00€ *
Review
Anti-RRM1
Anti-RRM1

Item number: A305-260A

Protein function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [The UniProt Consortium]
Keywords: Anti-RR1, Anti-RRM1, EC=1.17.4.1, Anti-Ribonucleotide reductase large subunit, Anti-Ribonucleoside-diphosphate reductase...
Application: WB, IP
Host: Rabbit
Species reactivity: human, mouse
From 164.00€ *
Review
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