68 products were found matching "K10170"!

CL075 is a toll-like receptor 8 (TLR8) agonist. It induces NF-kappaB activation in a reporter assay using HEK293 cells expressing recombinant human TLR8 and TNF-alpha production in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1 to 10 µM. In vivo, CL075 induces...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TLR8. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TLR8. Next,...

Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288. Protein function: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of...

R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections. At 1 µg/ml,...

CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8, Kd = 220 nM, IC50 = 67 nM in a reporter assay). It is selective for TLR8 over a panel of all other human TLRs when used at a concentration of 1 µM. CU-CPT8m (1 µM) inhibits increases in TNF-alpha and IL-8 mRNA expression induced by the TLR8 agonist R-848...

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor...

Anti-TLR8 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-TLR8 from human and mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-TLR8 from other sources has not been determined. Protein function: Key component of...

Motolimod is an agonist of toll-like receptor 8 (TLR8). It increases the production of TNF-alpha and IL-12 in human peripheral blood mononuclear cells (PBMCs, EC50s = 140 and 120 nM, respectively), monocytes, and myeloid dendritic cells. Motolimod also increases IFN-gamma production in natural killer (NK) cells and...

Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense...

Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense variant,...

Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense...

TLR8 (Toll-like Receptor 8) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR8 is a nucleotide-sensing TLR. TLR8 and TLR7 recognize single-stranded RNA (ssRNA) sequences containing GU-rich or poly-U sequences as their...