139 products were found matching "K09448"!

An inhibitor of the TEAD-YAP/TAZ protein-protein interaction, inhibits TEAD1-4 palmitoylation in HEK293T cells expressing TEAD1-4 at 3 µM, inhibits the proliferation of a variety of mesothelioma cells, including those with homozygous expression of NF2 mutations (GI50s = 8-74 nM) or heterozygous expression of NF2...

An inhibitor of TEAD autopalmitoylation, inhibits autopalmitoylation of TEAD1-4 in HEK293 cells expressing the human transcription factors at 3 µM, inhibits the growth of NCI-H2052, NCI-H2373, and NCI H226 cells (IC50s = 31.6, 25.6, and 16.1 nM, respectively), reduces tumor volume in an NCI H226 mouse xenograft...

Rabbit Polyclonal TEAD1 Antibody against Human TEA domain transcription factor 1. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000055320: 97%,...

Rabbit Polyclonal TEAD4 Antibody against Human TEA domain transcription factor 4. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000030353: 80%,...

A TEAD1 inhibitor (IC50 = 1.02 nM), inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2, TEAD3, or TEAD4 at 3 µM, inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells, reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models....

Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...

The TEAD Reporter - MCF7 cell line contains the firefly luciferase gene under the control of TEAD responsive elements stably integrated into the human breast cancer cell line, MCF7. Inside the cells, basal unphosphorylated YAP/TAZ remains in the nucleus and induces the constitutive expression of luciferase reporter....

Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...

Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...

Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...

Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: TEA domain family member 2 Protein function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by...