31 products were found matching "K09107"!

SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. SREBP-2 regulates cholesterol synthesis by activating the transcription...

Sterol regulatory element binding proteins (SREBPs) are transcription factors that have pivotal roles in lipogenesis and fat metabolism. The activation of SREBPs requires escort to the Golgi by SREBP cleavage-activating protein (SCAP) followed by proteolytic release of SREBP from the Golgi. Fatostatin is an...

Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated...

Protein function: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL...

Cayman's SREBP-2 Polyclonal Antibody - Biotinylated detects both precursor and active forms of the protein in tissues and cells such as liver, brown fat, testis, HepG2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to...

White solid. Soluble in DMSO, DMF or ethanol. Specific SREBPs (sterol regulatory element-binding proteins) inhibitor. Inhibits ER-Golgi translocation of SREBPs through binding to SCAP in an INSIG-dependent manner, Improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Lowers cholesterol...

The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1...

Protein function: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL...

Anti-ST3gal6 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ST3gal6 from other sources has not been determined. Protein function: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as...

Pentacyclic triterpene found in various plant sources.

In 1X PBS, pH 7.4, with 0.09% sodium azide. SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three...