59 products were found matching "K08960"!

PF-4800567 is a selective inhibitor of casein kinase 1epsilon (CK1epsilon, IC50 = 32 nM) with greater than 20-fold selectivity over CK1delta. It blocks CK1epsilon-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells. PF-4800567 has...

Protein function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1,...

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1epsilon and CK1delta (IC50 = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related...

Protein function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines...

Protein function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines...

Full length recombinant human CK1epsilon, also known as CSNK1E, HCKIE, MGC10398, and CK1E. Genbank Accession NM_001894 N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 72kDa.

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Casein kinase 1 epsilon Protein function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large...

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Cay-13067, Cay-13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 µM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the...

IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1delta and CK1? (IC50 = ~1 µM for both), as well as CK1alpha (IC50 = 16 µM). It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn. IC 261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts....

SR 3029 is an inhibitor of casein kinase 1delta (CK1delta) and CK1epsilon (IC50s = 44 and 260 nM, respectively). It is selective for CK1delta and CK1epsilon over 438 kinases in a panel but also inhibits MYLK4, FLT3, Cdk4/cyclin D1, and MARK2 by greater than 90% at 10 µM. SR 3029 inhibits Cdk4/cyclin D1, Cdk4/cyclin...

Protein function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1,...

Protein function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1,...