47 products were found matching "K08894"!

Human BRK, also known as PTK6 (GenBank Accession No. NM_005975), 2-451 (end), with N-terminal GST-tag, MW=80 kDa, expressed in Sf9 insect cells via a baculovirus expression system.

Tilfrinib is an inhibitor of breast tumor kinase/protein tyrosine kinase 6 (BRK/PTK6, IC50 = 3.15 nM). It is selective for BRK/PTK6 over HER2 (IC50 = 1,300 nM). Tilfrinib inhibits the growth of MCF-7, HS-578/T, and BT-549 breast cancer cells in vitro (GI50s = 0.99, 1.02, and 1.58 µM, respectively).Formal Name:...

Description: Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities. Target: BTK. Smiles: Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1. References: Mahmoud KA, et al. Discovery of 4-anilino alpha-carbolines as novel Brk...

Protein function: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular...

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase whicHuman, Mouseay function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially...

Protein function: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular...

Protein function: Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular...

The breast tumor kinase (BRK) Kinase Assay Kit is designed to measure BRK tyrosine kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PTK6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PTK6. Next,...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PTK6. Antigen Species: Human

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: PTK6. Antigen Species: Human